BEŠŠE, Lenka, Lenka SEDLAŘÍKOVÁ, Fedor KRYUKOV, Jana NEKVINDOVA, Lenka RADOVÁ, Ondřej SLABÝ, Petr KUGLÍK, Martina ALMASI, Miroslav PENKA, Marta KREJČÍ, Zdeněk ADAM, Luděk POUR, Sabina ŠEVČÍKOVÁ and Roman HÁJEK. Circulating Serum MicroRNA-130a as a Novel Putative Marker of Extramedullary Myeloma. Plos One. San Francisco: Public Library Science, 2015, vol. 10, No 9, p. "e0137294", 12 pp. ISSN 1932-6203. doi:10.1371/journal.pone.0137294.
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Basic information
Original name Circulating Serum MicroRNA-130a as a Novel Putative Marker of Extramedullary Myeloma
Authors BEŠŠE, Lenka (203 Czech Republic, belonging to the institution), Lenka SEDLAŘÍKOVÁ (203 Czech Republic, belonging to the institution), Fedor KRYUKOV (643 Russian Federation, belonging to the institution), Jana NEKVINDOVA (203 Czech Republic), Lenka RADOVÁ (203 Czech Republic, belonging to the institution), Ondřej SLABÝ (203 Czech Republic, belonging to the institution), Petr KUGLÍK (203 Czech Republic, belonging to the institution), Martina ALMASI (203 Czech Republic), Miroslav PENKA (203 Czech Republic, belonging to the institution), Marta KREJČÍ (203 Czech Republic), Zdeněk ADAM (203 Czech Republic), Luděk POUR (203 Czech Republic), Sabina ŠEVČÍKOVÁ (203 Czech Republic, guarantor, belonging to the institution) and Roman HÁJEK (203 Czech Republic, belonging to the institution).
Edition Plos One, San Francisco, Public Library Science, 2015, 1932-6203.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.057
RIV identification code RIV/00216224:14110/15:00084098
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1371/journal.pone.0137294
UT WoS 000361791000006
Keywords in English MULTIPLE-MYELOMA
Tags EL OK, podil
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 29. 10. 2015 12:23.
Abstract
Poor outcome of extramedullary disease in multiple myeloma patients and lack of outcome predictors prompt continued search for new markers of the disease. In this report, we show circulating microRNA distinguishing multiple myeloma patients with extramedullary disease from myeloma patients without such manifestation and from healthy donors. MicroRNA-130a was identified by TaqMan Low Density Arrays and verified by quantitative PCR on 144 serum samples (59 multiple myeloma, 55 myeloma with extramedullary disease, 30 healthy donors) in test and validation cohorts as being down-regulated in myeloma patients with extramedullary disease. Circulating microRNA-130a distinguished myeloma patients with extramedullary disease from healthy donors with specificity of 90.0% and sensitivity of 77.1%, patients with extramedullary disease from newly diagnosed multiple myeloma patients with specificity of 77.1% and sensitivity of 34.3% in the test cohort and with specificity of 91.7% and sensitivity of 30.0% in the validation cohort of patients. Circulating microRNA-130a in patients with extramedullary myeloma was associated with bone marrow plasma cells infiltration. Further, microRNA-130a was decreased in bone marrow plasma cells obtained from patients with extramedullary myeloma in comparison to bone marrow plasma cells of myeloma patients without such manifestation, but it was increased in tumor site plasma cells of patients with extramedullary disease compared to bone marrow plasma cells of such patients (p<0.0001). Together, our data suggest connection between lower level of microRNA-130a and extramedullary disease and prompt further work to evaluate this miRNA as a marker of extramedullary disease in multiple myeloma.
Links
MUNI/11/InGA17/2012, interní kód MUName: MikroRNA v patogenezi extramedulárního relapsu mnohočetného myelomu
Investor: Masaryk University
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