BARTÁKOVÁ, Vendula, Denisa MALÚŠKOVÁ, Jan MUŽÍK, Jana BĚLOBRÁDKOVÁ and Kateřina KAŇKOVÁ. Possibility to predict early postpartum glucose abnormality following gestational diabetes mellitus based on the results of routine mid-gestational screening. Biochemia medica. Zagreb: Croatian Society of Medical Biochemistry and Laboratory Medicine, 2015, vol. 25, No 3, p. 460-468. ISSN 1330-0962. Available from: https://dx.doi.org/10.11613/BM.2015.047. |
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@article{1313044, author = {Bartáková, Vendula and Malúšková, Denisa and Mužík, Jan and Bělobrádková, Jana and Kaňková, Kateřina}, article_location = {Zagreb}, article_number = {3}, doi = {http://dx.doi.org/10.11613/BM.2015.047}, keywords = {gestational diabetes; oral glucose tolerance test; postpartum period; glucose intolerance; diagnosis}, language = {eng}, issn = {1330-0962}, journal = {Biochemia medica}, title = {Possibility to predict early postpartum glucose abnormality following gestational diabetes mellitus based on the results of routine mid-gestational screening}, url = {http://www.biochemia-medica.com/system/files/Bartakova%20V.et%20al.-%20Possibility%20to%20predict%20early%20postpartum%20glucose%20abnormality.pdf}, volume = {25}, year = {2015} }
TY - JOUR ID - 1313044 AU - Bartáková, Vendula - Malúšková, Denisa - Mužík, Jan - Bělobrádková, Jana - Kaňková, Kateřina PY - 2015 TI - Possibility to predict early postpartum glucose abnormality following gestational diabetes mellitus based on the results of routine mid-gestational screening JF - Biochemia medica VL - 25 IS - 3 SP - 460-468 EP - 460-468 PB - Croatian Society of Medical Biochemistry and Laboratory Medicine SN - 13300962 KW - gestational diabetes KW - oral glucose tolerance test KW - postpartum period KW - glucose intolerance KW - diagnosis UR - http://www.biochemia-medica.com/system/files/Bartakova%20V.et%20al.-%20Possibility%20to%20predict%20early%20postpartum%20glucose%20abnormality.pdf N2 - Introduction: Women with previous gestational diabetes mellitus (GDM) have increased risk of developing glucose abnormality, but current diagnostic criteria are evidence-based for adverse pregnancy outcome. The aims of our study were: (i) to ascertain a frequency of early conversion of GDM into permanent glucose abnormality, (ii) to determine predictive potential of current GDM diagnostic criteria for prediction of postpartum glucose abnormality and (iii) to find optimal cut-off values of oral glucose tolerance test (oGTT) to stratify GDM population according to postpartum risk. Materials and methods: Electronic medical records of an ethnically homogenous cohort of women diagnosed and treated for GDM in a single medical centre during the period 2005–2011 who completed postpartum oGTT up to 1 year after the index delivery were retrospectively analysed (N = 305). Results: Postpartum glucose abnormality was detected in 16.7% subjects. Mid-trimester oGTT values, respective area under the curve and HbA1c were significantly associated with early postpartum glucose abnormality (P < 0.05, Mann-Whitney) and exhibited significant predictive potential for postpartum glucose abnormality risk assessment. Optimal cut-off values for discrimination of at-risk sub-population were identified using ROC analysis and their comparison with WHO and IADPSG criteria exhibited superiority of IADPSG for risk-stratification of GDM population. Conclusion: Risk-based stratification at the time of GDM diagnosis could improve efficiency of the post-gestational screening for diabetes. IADPSG criteria seem to optimally capture both perinatal and maternal metabolic risks and are therefore medically and economically justified. ER -
BARTÁKOVÁ, Vendula, Denisa MALÚŠKOVÁ, Jan MUŽÍK, Jana BĚLOBRÁDKOVÁ and Kateřina KAŇKOVÁ. Possibility to predict early postpartum glucose abnormality following gestational diabetes mellitus based on the results of routine mid-gestational screening. \textit{Biochemia medica}. Zagreb: Croatian Society of Medical Biochemistry and Laboratory Medicine, 2015, vol.~25, No~3, p.~460-468. ISSN~1330-0962. Available from: https://dx.doi.org/10.11613/BM.2015.047.
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