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@article{1313267,
author = {Veselá, Barbora and Švandová, Eva and Tom, Vanden Berghe and Abigail S, Tucker and Vandenabeele, Peter and Matalová, Eva},
article_number = {4-5},
doi = {http://dx.doi.org/10.1007/s10735-015-9636-1},
keywords = {Caspase-7; Development; Hair follicles; Mast cells; Non-apoptotic},
language = {eng},
issn = {1567-2379},
journal = {Journal of Molecular Histology},
title = {Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue},
url = {http://link.springer.com/article/10.1007%2Fs10735-015-9636-1},
volume = {46},
year = {2015}
}
TY - JOUR
ID - 1313267
AU - Veselá, Barbora - Švandová, Eva - Tom, Vanden Berghe - Abigail S, Tucker - Vandenabeele, Peter - Matalová, Eva
PY - 2015
TI - Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue
JF - Journal of Molecular Histology
VL - 46
IS - 4-5
SP - 443-455
EP - 443-455
PB - Kluwer Academic Publishers
SN - 15672379
KW - Caspase-7
KW - Development
KW - Hair follicles
KW - Mast cells
KW - Non-apoptotic
UR - http://link.springer.com/article/10.1007%2Fs10735-015-9636-1
L2 - http://link.springer.com/article/10.1007%2Fs10735-015-9636-1
N2 - Hair follicles are unique organs undergoing regular cycles of proliferation, differentiation, and apoptosis. The final step of apoptosis is, in general, mediated by executioner caspases comprising caspase-3, -6 and -7. Despite their commonly accepted apoptotic function, executioner caspases also participate in non-apoptotic processes. In the present study, we investigated activation (cleavage) of caspase-7 in mouse hair follicles and surrounding tissue during embryonic development into adulthood. Casp7 (-/-) mice were examined to understand the effect of caspase-7 deficiency in the skin. The activated form of caspase-7 was observed during embryonic hair follicle development, as well as in the first hair cycle. In general, activation of caspase-7 did not correlate with apoptosis and activation of caspase-3, except during physiological hair follicle regression. Notably, cleaved caspase-7 was observed in mast cells and its deficiency in the adult skin resulted in increased mast cell number. Our study shows for the first time activated caspase-7 in hair follicles and mast cells and indicates its non-apoptotic roles in the skin.
ER -
VESELÁ, Barbora, Eva ŠVANDOVÁ, Vanden Berghe TOM, Tucker ABIGAIL S, Peter VANDENABEELE a Eva MATALOVÁ. Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue. \textit{Journal of Molecular Histology}. Kluwer Academic Publishers, 2015, roč.~46, 4-5, s.~443-455. ISSN~1567-2379. Dostupné z: https://dx.doi.org/10.1007/s10735-015-9636-1.
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