| ÖSTERBORG, Anders, William G. WIERDA, Jiří MAYER, Georg HESS, Peter HILLMEN, Johannes SCHETELIG, Anna SCHUH, Lukáš SMOLEJ, Christian BECK, Brigitte DREYFUS, Andrzej HELLMAN, Piotr KOZLOWSKI, Michael PFREUNDSCHUH, Rita RIZZI, Martin SPACEK, Jennifer L. PHILLIPS, Iira V. GUPTA, Vanessa WILLIAMS, Roxane C. JEWELL, Noelia NEBOT, Steen LISBY a Martin J.S. DYER. Ofatumumab retreatment and maintenance in fludarabine-refractory chronic lymphocytic leukaemia patients. British journal of haematology. Hoboken: Wiley-Blackwell, roč. 170, č. 1, s. 40-49. ISSN 0007-1048. doi:10.1111/bjh.13380. 2015. |
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@article{1313272,
author = {Österborg, Anders and Wierda, William G. and Mayer, Jiří and Hess, Georg and Hillmen, Peter and Schetelig, Johannes and Schuh, Anna and Smolej, Lukáš and Beck, Christian and Dreyfus, Brigitte and Hellman, Andrzej and Kozlowski, Piotr and Pfreundschuh, Michael and Rizzi, Rita and Spacek, Martin and Phillips, Jennifer L. and Gupta, Iira V. and Williams, Vanessa and Jewell, Roxane C. and Nebot, Noelia and Lisby, Steen and Dyer, Martin J.S.},
article_location = {Hoboken},
article_number = {1},
doi = {http://dx.doi.org/10.1111/bjh.13380},
keywords = {ofatumumab; chronic lymphocytic leukaemia; anti-CD20 monoclonal antibody; retreatment; maintenance},
language = {eng},
issn = {0007-1048},
journal = {British journal of haematology},
title = {Ofatumumab retreatment and maintenance in fludarabine-refractory chronic lymphocytic leukaemia patients},
volume = {170},
year = {2015}
}
TY - JOUR
ID - 1313272
AU - Österborg, Anders - Wierda, William G. - Mayer, Jiří - Hess, Georg - Hillmen, Peter - Schetelig, Johannes - Schuh, Anna - Smolej, Lukáš - Beck, Christian - Dreyfus, Brigitte - Hellman, Andrzej - Kozlowski, Piotr - Pfreundschuh, Michael - Rizzi, Rita - Spacek, Martin - Phillips, Jennifer L. - Gupta, Iira V. - Williams, Vanessa - Jewell, Roxane C. - Nebot, Noelia - Lisby, Steen - Dyer, Martin J.S.
PY - 2015
TI - Ofatumumab retreatment and maintenance in fludarabine-refractory chronic lymphocytic leukaemia patients
JF - British journal of haematology
VL - 170
IS - 1
SP - 40-49
EP - 40-49
PB - Wiley-Blackwell
SN - 00071048
KW - ofatumumab
KW - chronic lymphocytic leukaemia
KW - anti-CD20 monoclonal antibody
KW - retreatment
KW - maintenance
N2 - There are limited data on retreatment with monoclonal antibodies (mAb) in patients with chronic lymphocytic leukaemia (CLL). In a pivotal study, ofatumumab (human anti-CD20 mAb) monotherapy demonstrated a 47% objective response rate (ORR) in fludarabine refractory CLL patients. From this study, a subset of 29 patients who had at least stable disease and then progressed were retreated with eight weekly ofatumumab infusions (induction treatment period), followed by monthly infusions for up to 2years (maintenance treatment period). The ORR after 8weeks of induction retreatment was 45% and 24% had continued disease control after maintenance at 52weeks. Efficacy and safety of the retreated patients were compared with their initial results in the pivotal study. Response duration was 241months vs. 68months; time to next therapy was 148months vs. 123months; and progression-free survival was 74months vs. 79months (medians). Upon retreatment, 72% had infusion reactions, mostly Grade 1-2. Three patients had fatal infections. In summary, ofatumumab retreatment and maintenance therapy was feasible in patients with heavily pretreated CLL and appeared to result in more durable disease control than initial ofatumumab treatment in this subset of patients who may have a more favourable disease profile.
ER -
ÖSTERBORG, Anders, William G. WIERDA, Jiří MAYER, Georg HESS, Peter HILLMEN, Johannes SCHETELIG, Anna SCHUH, Lukáš SMOLEJ, Christian BECK, Brigitte DREYFUS, Andrzej HELLMAN, Piotr KOZLOWSKI, Michael PFREUNDSCHUH, Rita RIZZI, Martin SPACEK, Jennifer L. PHILLIPS, Iira V. GUPTA, Vanessa WILLIAMS, Roxane C. JEWELL, Noelia NEBOT, Steen LISBY a Martin J.S. DYER. Ofatumumab retreatment and maintenance in fludarabine-refractory chronic lymphocytic leukaemia patients. \textit{British journal of haematology}. Hoboken: Wiley-Blackwell, roč.~170, č.~1, s.~40-49. ISSN~0007-1048. doi:10.1111/bjh.13380. 2015.
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