VLKOVÁ, Marcela, Olga TICHÁ, Jana NECHVÁTALOVÁ, Tomas KALINA, Jiří LITZMAN, Claudia MAURI a Paul A. BLAIR. Regulatory B cells in CVID patients fail to suppress multifunctional IFN-gamma+TNF-alpha(+)CD4(+) T cells differentiation. Clinical Immunology. San Diego: Academic Press Inc. Elsevier Science, 2015, roč. 160, č. 2, s. 292-300. ISSN 1521-6616. Dostupné z: https://dx.doi.org/10.1016/j.clim.2015.06.013. |
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@article{1313280, author = {Vlková, Marcela and Tichá, Olga and Nechvátalová, Jana and Kalina, Tomas and Litzman, Jiří and Mauri, Claudia and Blair, Paul A.}, article_location = {San Diego}, article_number = {2}, doi = {http://dx.doi.org/10.1016/j.clim.2015.06.013}, keywords = {B cell; Common variable immunodeficiency (CVID); Cytokine production; Flow cytometry; T cell}, language = {eng}, issn = {1521-6616}, journal = {Clinical Immunology}, title = {Regulatory B cells in CVID patients fail to suppress multifunctional IFN-gamma+TNF-alpha(+)CD4(+) T cells differentiation}, volume = {160}, year = {2015} }
TY - JOUR ID - 1313280 AU - Vlková, Marcela - Tichá, Olga - Nechvátalová, Jana - Kalina, Tomas - Litzman, Jiří - Mauri, Claudia - Blair, Paul A. PY - 2015 TI - Regulatory B cells in CVID patients fail to suppress multifunctional IFN-gamma+TNF-alpha(+)CD4(+) T cells differentiation JF - Clinical Immunology VL - 160 IS - 2 SP - 292-300 EP - 292-300 PB - Academic Press Inc. Elsevier Science SN - 15216616 KW - B cell KW - Common variable immunodeficiency (CVID) KW - Cytokine production KW - Flow cytometry KW - T cell N2 - Common variable immunodeficiency (CVID) refers to primary hypogammaglobulinemia with unknown pathogenesis. Although there is evidence for intrinsic B cell defects in some CVID patient groups, various abnormalities in cytokine production by T cells in CVID patients are frequently observed. Here, we demonstrate a relationship in the production of pro-inflammatory Th1 cytokines and regulatory B cells producing IL-10 between CVID patients and healthy controls. We describe CD19+CD24hiCD38hiIL-10+ regulatory B cells generated after T cell stimulation of human peripheral blood lymphocytes ex vivo are able to suppress IFN-gamma+TNF-alpha+ producing CD4+ T cells. This process is impaired in CVID patients, who present with both low numbers of CD19+CD24hiCD38hiIL-10+ B cells and increased numbers of IFN-gamma+TNF-alpha+CD4+ T cells. Disruption of the regulatory B cell response to T cell stimulation explains the excessive T cell activation regarded as an immunoregulatory abnormality that is a frequent finding in CVID patients. ER -
VLKOVÁ, Marcela, Olga TICHÁ, Jana NECHVÁTALOVÁ, Tomas KALINA, Jiří LITZMAN, Claudia MAURI a Paul A. BLAIR. Regulatory B cells in CVID patients fail to suppress multifunctional IFN-gamma+TNF-alpha(+)CD4(+) T cells differentiation. \textit{Clinical Immunology}. San Diego: Academic Press Inc. Elsevier Science, 2015, roč.~160, č.~2, s.~292-300. ISSN~1521-6616. Dostupné z: https://dx.doi.org/10.1016/j.clim.2015.06.013.
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