| VLKOVÁ, Marcela, Olga TICHÁ, Jana NECHVÁTALOVÁ, Tomas KALINA, Jiří LITZMAN, Claudia MAURI and Paul A. BLAIR. Regulatory B cells in CVID patients fail to suppress multifunctional IFN-gamma+TNF-alpha(+)CD4(+) T cells differentiation. Clinical Immunology. San Diego: Academic Press Inc. Elsevier Science, vol. 160, No 2, p. 292-300. ISSN 1521-6616. doi:10.1016/j.clim.2015.06.013. 2015. |
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@article{1313280,
author = {Vlková, Marcela and Tichá, Olga and Nechvátalová, Jana and Kalina, Tomas and Litzman, Jiří and Mauri, Claudia and Blair, Paul A.},
article_location = {San Diego},
article_number = {2},
doi = {http://dx.doi.org/10.1016/j.clim.2015.06.013},
keywords = {B cell; Common variable immunodeficiency (CVID); Cytokine production; Flow cytometry; T cell},
language = {eng},
issn = {1521-6616},
journal = {Clinical Immunology},
title = {Regulatory B cells in CVID patients fail to suppress multifunctional IFN-gamma+TNF-alpha(+)CD4(+) T cells differentiation},
volume = {160},
year = {2015}
}
TY - JOUR
ID - 1313280
AU - Vlková, Marcela - Tichá, Olga - Nechvátalová, Jana - Kalina, Tomas - Litzman, Jiří - Mauri, Claudia - Blair, Paul A.
PY - 2015
TI - Regulatory B cells in CVID patients fail to suppress multifunctional IFN-gamma+TNF-alpha(+)CD4(+) T cells differentiation
JF - Clinical Immunology
VL - 160
IS - 2
SP - 292-300
EP - 292-300
PB - Academic Press Inc. Elsevier Science
SN - 15216616
KW - B cell
KW - Common variable immunodeficiency (CVID)
KW - Cytokine production
KW - Flow cytometry
KW - T cell
N2 - Common variable immunodeficiency (CVID) refers to primary hypogammaglobulinemia with unknown pathogenesis. Although there is evidence for intrinsic B cell defects in some CVID patient groups, various abnormalities in cytokine production by T cells in CVID patients are frequently observed. Here, we demonstrate a relationship in the production of pro-inflammatory Th1 cytokines and regulatory B cells producing IL-10 between CVID patients and healthy controls. We describe CD19+CD24hiCD38hiIL-10+ regulatory B cells generated after T cell stimulation of human peripheral blood lymphocytes ex vivo are able to suppress IFN-gamma+TNF-alpha+ producing CD4+ T cells. This process is impaired in CVID patients, who present with both low numbers of CD19+CD24hiCD38hiIL-10+ B cells and increased numbers of IFN-gamma+TNF-alpha+CD4+ T cells. Disruption of the regulatory B cell response to T cell stimulation explains the excessive T cell activation regarded as an immunoregulatory abnormality that is a frequent finding in CVID patients.
ER -
VLKOVÁ, Marcela, Olga TICHÁ, Jana NECHVÁTALOVÁ, Tomas KALINA, Jiří LITZMAN, Claudia MAURI and Paul A. BLAIR. Regulatory B cells in CVID patients fail to suppress multifunctional IFN-gamma+TNF-alpha(+)CD4(+) T cells differentiation. \textit{Clinical Immunology}. San Diego: Academic Press Inc. Elsevier Science, vol.~160, No~2, p.~292-300. ISSN~1521-6616. doi:10.1016/j.clim.2015.06.013. 2015.
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