VLKOVÁ, Marcela, Olga TICHÁ, Jana NECHVÁTALOVÁ, Tomas KALINA, Jiří LITZMAN, Claudia MAURI and Paul A. BLAIR. Regulatory B cells in CVID patients fail to suppress multifunctional IFN-gamma+TNF-alpha(+)CD4(+) T cells differentiation. Clinical Immunology. San Diego: Academic Press Inc. Elsevier Science, 2015, vol. 160, No 2, p. 292-300. ISSN 1521-6616. doi:10.1016/j.clim.2015.06.013.
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Basic information
Original name Regulatory B cells in CVID patients fail to suppress multifunctional IFN-gamma+TNF-alpha(+)CD4(+) T cells differentiation
Authors VLKOVÁ, Marcela (203 Czech Republic, belonging to the institution), Olga TICHÁ (203 Czech Republic, belonging to the institution), Jana NECHVÁTALOVÁ (203 Czech Republic, belonging to the institution), Tomas KALINA (203 Czech Republic), Jiří LITZMAN (203 Czech Republic, belonging to the institution), Claudia MAURI (203 Czech Republic) and Paul A. BLAIR (826 United Kingdom of Great Britain and Northern Ireland).
Edition Clinical Immunology, San Diego, Academic Press Inc. Elsevier Science, 2015, 1521-6616.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30102 Immunology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 4.034
RIV identification code RIV/00216224:14110/15:00084180
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.clim.2015.06.013
UT WoS 000362151500019
Keywords in English B cell; Common variable immunodeficiency (CVID); Cytokine production; Flow cytometry; T cell
Tags EL OK
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 3/11/2015 15:07.
Abstract
Common variable immunodeficiency (CVID) refers to primary hypogammaglobulinemia with unknown pathogenesis. Although there is evidence for intrinsic B cell defects in some CVID patient groups, various abnormalities in cytokine production by T cells in CVID patients are frequently observed. Here, we demonstrate a relationship in the production of pro-inflammatory Th1 cytokines and regulatory B cells producing IL-10 between CVID patients and healthy controls. We describe CD19+CD24hiCD38hiIL-10+ regulatory B cells generated after T cell stimulation of human peripheral blood lymphocytes ex vivo are able to suppress IFN-gamma+TNF-alpha+ producing CD4+ T cells. This process is impaired in CVID patients, who present with both low numbers of CD19+CD24hiCD38hiIL-10+ B cells and increased numbers of IFN-gamma+TNF-alpha+CD4+ T cells. Disruption of the regulatory B cell response to T cell stimulation explains the excessive T cell activation regarded as an immunoregulatory abnormality that is a frequent finding in CVID patients.
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EE2.3.30.0009, research and development projectName: Zaměstnáním čerstvých absolventů doktorského studia k vědecké excelenci
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