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@article{1313669,
author = {Bešše, Lenka and Sedlaříková, Lenka and Grešliková, Henrieta and Kupská, Renata and Almasi, Martina and Penka, Miroslav and Jelinek, Tomas and Pour, Luděk and Adam, Zdeněk and Kuglík, Petr and Krejčí, Marta and Hájek, Roman and Ševčíková, Sabina},
article_location = {Hoboken},
article_number = {1},
doi = {http://dx.doi.org/10.1111/ejh.12688},
keywords = {multiple myeloma; extramedullary relapse; cytogenetics},
language = {eng},
issn = {0902-4441},
journal = {European Journal of Haematology},
title = {Cytogenetics in multiple myeloma patients progressing into extramedullary disease},
volume = {97},
year = {2016}
}
TY - JOUR
ID - 1313669
AU - Bešše, Lenka - Sedlaříková, Lenka - Grešliková, Henrieta - Kupská, Renata - Almasi, Martina - Penka, Miroslav - Jelinek, Tomas - Pour, Luděk - Adam, Zdeněk - Kuglík, Petr - Krejčí, Marta - Hájek, Roman - Ševčíková, Sabina
PY - 2016
TI - Cytogenetics in multiple myeloma patients progressing into extramedullary disease
JF - European Journal of Haematology
VL - 97
IS - 1
SP - 93-100
EP - 93-100
PB - Wiley-Blackwell
SN - 09024441
KW - multiple myeloma
KW - extramedullary relapse
KW - cytogenetics
N2 - BACKGROUND: Extramedullary disease in multiple myeloma patients is an uncommon event occurring either at the time of diagnosis, or during disease progression/relapse. This manifestation is frequently associated with poor outcome and resistance to treatment. We evaluated chromosomal alterations of plasma cells of multiple myeloma patients with extramedullary relapse, either in the bone marrow or at extramedullary sites, and in previous bone marrow collection by I-FISH. MATERIAL AND METHODS: Thirty one patients (25 bone marrow plasma cells, 18 extramedullary tumor plasma cells), of which 12 had paired samples of bone marrow and extramedullary plasma cells and 14 had previous collection of bone marrow, were investigated for the presence of chromosomal aberrations: del(17)(p13), del(13)(q14), 14q32 disruption, t(4;14)(p16;q32), t(14;16)(q32;q23), gain(1)(q21) and hyperdiploidy status. RESULTS: Overall, in unrelated samples, t(4;14) was more prevalent in extramedullary plasma cells, and hyperdiploidy was more frequent in bone marrow plasma cells. In paired samples, there was a higher frequency of del(13)(q14) and 14q32 disruption in bone marrow plasma cells. Frequency of all studied chromosomal aberrations was higher in bone marrow plasma cells of extramedullary patients than in their previous sample collection. CONCLUSION: These data show that plasma cells harbor more aberrations during their transformation into extramedullary form.
ER -
BEŠŠE, Lenka, Lenka SEDLAŘÍKOVÁ, Henrieta GREŠLIKOVÁ, Renata KUPSKÁ, Martina ALMASI, Miroslav PENKA, Tomas JELINEK, Luděk POUR, Zdeněk ADAM, Petr KUGLÍK, Marta KREJČÍ, Roman HÁJEK and Sabina ŠEVČÍKOVÁ. Cytogenetics in multiple myeloma patients progressing into extramedullary disease. \textit{European Journal of Haematology}. Hoboken: Wiley-Blackwell, 2016, vol.~97, No~1, p.~93-100. ISSN~0902-4441. Available from: https://dx.doi.org/10.1111/ejh.12688.
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