Investigating the amoebicidal activity of Indonesian plant
extracts possibly used as medicinal plants by orangutans

k 2015

Investigating the amoebicidal activity of Indonesian plant extracts possibly used as medicinal plants by orangutans

STUART, Peter Daniel, Ibne ALI, Karel DOLEŽAL, Erhan YALCINDAG, Radka PECKOVÁ et. al.

Basic information

Original name

Investigating the amoebicidal activity of Indonesian plant extracts possibly used as medicinal plants by orangutans

Authors

STUART, Peter Daniel (372 Ireland, belonging to the institution), Ibne ALI (356 India), Karel DOLEŽAL (372 Ireland), Erhan YALCINDAG (792 Turkey), Radka PECKOVÁ (203 Czech Republic, belonging to the institution), Milan OLŠANSKÝ (203 Czech Republic), Wisnu NURCAHYO (360 Indonesia) and Ivona FOITOVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) San Diego 2015, 2015

Other information

Language

English

Type of outcome

Prezentace na konferencích

Field of Study

40301 Veterinary science

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

website

RIV identification code

RIV/00216224:14310/15:00081110

Organization unit

Faculty of Science

Keywords in English

Entamoeba; Orangutan; Parasite; Disease; Plant extract

Změněno: 1/4/2016 10:19, Mgr. Lucie Jarošová, DiS.

Abstract

V originále

Presenter’s Email: peterdstuart@hotmail.com Amoebiasis, the condition that results from infection with Entamoeba histolytica, is a major global health concern. Infection is common in the tropics, including South-East Asia. Infection can also occur in non-human primates and most recently has been observed in wild orangutans (Pongo sp.). Plants from Indonesia were selected to be tested for activity against E. histolytica, based on observations that orangutans were consuming them more when infected with parasitic protozoa. Methanol and Methanol:Tetrahydrofuran crude extracts were obtained from four plants: Achidendron fagifollium, Diospyros sumatra, Piper betle and Shorea sumatrana. Of these D. sumatra and P. betle showed activity against E. histolytica (IC50 <47microg/ml and IC50 <67 mikrog/ml respectively). The results support the use of these plants for dysentery by local people. They also demonstrate for the first time, that orangutans may be directly self-medicating. Preliminary trials of these plants on N. fowleri suggest further trials are warranted.

Links

GAP505/11/1163, research and development project

Name: Protizánětlivá aktivita extraktů z rostlin Indonésie a jejich účinek na průběh oportunních parazitóz

Investor: Czech Science Foundation

Citovat

STUART, Peter Daniel, Ibne ALI, Karel DOLEŽAL, Erhan YALCINDAG, Radka PECKOVÁ, Milan OLŠANSKÝ, Wisnu NURCAHYO and Ivona FOITOVÁ. Investigating the amoebicidal activity of Indonesian plant extracts possibly used as medicinal plants by orangutans. In Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) San Diego 2015. 2015.

@proceedings{1313841,
   author = {Stuart, Peter Daniel and Ali, Ibne and Doležal, Karel and Yalcindag, Erhan and Pecková, Radka and Olšanský, Milan and Nurcahyo, Wisnu and Foitová, Ivona},
   booktitle = {Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) San Diego 2015},
   keywords = {Entamoeba; Orangutan; Parasite; Disease; Plant extract},
   language = {eng},
   title = {Investigating the amoebicidal activity of Indonesian plant extracts possibly used as medicinal plants by orangutans},
   url = {http://www.icaac.org/},
   year = {2015}
}

TY  - CONF
ID  - 1313841
AU  - Stuart, Peter Daniel - Ali, Ibne - Doležal, Karel - Yalcindag, Erhan - Pecková, Radka - Olšanský, Milan - Nurcahyo, Wisnu - Foitová, Ivona
PY  - 2015
TI  - Investigating the amoebicidal activity of Indonesian plant extracts possibly used as medicinal plants by orangutans
KW  - Entamoeba
KW  - Orangutan
KW  - Parasite
KW  - Disease
KW  - Plant extract
UR  - http://www.icaac.org/
L2  - http://www.icaac.org/
N2  - Presenter’s Email: peterdstuart@hotmail.com Amoebiasis, the condition that results from infection with Entamoeba histolytica, is a major global health concern. Infection is common in the tropics, including South-East Asia. Infection can also occur in non-human primates and most recently has been observed in wild orangutans (Pongo sp.). Plants from Indonesia were selected to be tested for activity against E. histolytica, based on observations that orangutans were consuming them more when infected with parasitic protozoa. Methanol and Methanol:Tetrahydrofuran crude extracts were obtained from four plants: Achidendron fagifollium, Diospyros sumatra, Piper betle and Shorea sumatrana. Of these D. sumatra and P. betle showed activity against E. histolytica (IC50 <47microg/ml and IC50 <67 mikrog/ml respectively). The results support the use of these plants for dysentery by local people. They also demonstrate for the first time, that orangutans may be directly self-medicating. Preliminary trials of these plants on N. fowleri suggest further trials are warranted.
ER  -

STUART, Peter Daniel, Ibne ALI, Karel DOLEŽAL, Erhan YALCINDAG, Radka PECKOVÁ, Milan OLŠANSKÝ, Wisnu NURCAHYO and Ivona FOITOVÁ. Investigating the amoebicidal activity of Indonesian plant extracts possibly used as medicinal plants by orangutans. In \textit{Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) San Diego 2015}. 2015.

Detailed Information on Publication Record