The bioinformatic analyses of “-omes” of helminths with special
focus on serine peptidases of Eudiplozoon nipponicum

k 2014

The bioinformatic analyses of “-omes” of helminths with special focus on serine peptidases of Eudiplozoon nipponicum

VOREL, Jiří, Hana DVOŘÁKOVÁ, Lucie JEDLIČKOVÁ, Libor MIKEŠ, Milan GELNAR et. al.

Basic information

Original name

The bioinformatic analyses of “-omes” of helminths with special focus on serine peptidases of Eudiplozoon nipponicum

Name in Czech

Bioinformatické analýzy „–omů“ parazitických červů se zaměřením na serinové peptidázy Eudiplozoon nipponicum.

Authors

VOREL, Jiří (203 Czech Republic, belonging to the institution), Hana DVOŘÁKOVÁ (203 Czech Republic), Lucie JEDLIČKOVÁ (203 Czech Republic), Libor MIKEŠ (203 Czech Republic), Milan GELNAR (203 Czech Republic, belonging to the institution) and Martin KAŠNÝ (203 Czech Republic, guarantor, belonging to the institution)

Edition

21st Helminthological Days, 2014

Other information

Language

English

Type of outcome

Prezentace na konferencích

Field of Study

10600 1.6 Biological sciences

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14310/14:00095801

Organization unit

Faculty of Science

ISBN

978-80-210-6796-7

Keywords in English

Sequencing; NGS data processing; Transcriptomics; Helminths; Eudiplozoon nipponicum; Serine peptidases

Změněno: 16/2/2018 14:32, Mgr. Jiří Vorel, Ph.D.

Abstract

V originále

Parasitic helminths are causative agents of number of serious diseases (helminthiasis) of animals and people. Our understanding to the biological processes of helminths is based also on detailed knowledge of their molecular biology and biochemistry. By using the modern pyro-sequencing methods and computer databases (genomic, transcriptomic and proteomic) we can now faster and more accurately identify numerous sets of protein molecules which are essential for life of parasites. Since September 2011 the “50 Helminth Genomes Project” is running, but from a large group of Monogenea only one species is currently sequenced - Protopolystoma xenopodis. We would like to change this situation and therefore we adopted Eudiplozoon nipponicum (Monogenea: Diplozoidae) as a model organism and started some preliminary analyses leaded to generation of E. nipponicum genome, transcriptome and proteome databases. We would like to use data platforms for identification and further characterization of protein molecules involved into the interaction between host and parasite. Our preliminary transcriptome results suggest that such molecules could be serine peptidases. Serine peptidases are molecules essential for life in all organism including parasitic helminths. These molecules help them to penetrate the defensive barriers and avoid the immune attack of the host. Hematophagous parasites allows digest blood and obtain necessary nutrients.

Links

MUNI/A/0888/2013, interní kód MU

Name: Biodiverzita - analýzy biologických systémů různých úrovní a na různých škálách prostředí (Acronym: BIDA3)

Investor: Masaryk University, Category A

Citovat

VOREL, Jiří, Hana DVOŘÁKOVÁ, Lucie JEDLIČKOVÁ, Libor MIKEŠ, Milan GELNAR and Martin KAŠNÝ. The bioinformatic analyses of “-omes” of helminths with special focus on serine peptidases of Eudiplozoon nipponicum. In 21st Helminthological Days. 2014. ISBN 978-80-210-6796-7.

@proceedings{1313933,
   author = {Vorel, Jiří and Dvořáková, Hana and Jedličková, Lucie and Mikeš, Libor and Gelnar, Milan and Kašný, Martin},
   booktitle = {21st Helminthological Days},
   keywords = {Sequencing; NGS data processing; Transcriptomics; Helminths; Eudiplozoon nipponicum; Serine peptidases},
   language = {eng},
   isbn = {978-80-210-6796-7},
   title = {The bioinformatic analyses of “-omes” of helminths with special focus on serine peptidases of Eudiplozoon nipponicum},
   year = {2014}
}

TY  - CONF
ID  - 1313933
AU  - Vorel, Jiří - Dvořáková, Hana - Jedličková, Lucie - Mikeš, Libor - Gelnar, Milan - Kašný, Martin
PY  - 2014
TI  - The bioinformatic analyses of “-omes” of helminths with special focus on serine peptidases of Eudiplozoon nipponicum
SN  - 9788021067967
KW  - Sequencing
KW  - NGS data processing
KW  - Transcriptomics
KW  - Helminths
KW  - Eudiplozoon nipponicum
KW  - Serine peptidases
N2  - Parasitic helminths are causative agents of number of serious diseases (helminthiasis) of animals and people. Our understanding to the biological processes of helminths is based also on detailed knowledge of their molecular biology and biochemistry. By using the modern pyro-sequencing methods and computer databases (genomic, transcriptomic and proteomic) we can now faster and more accurately identify numerous sets of protein molecules which are essential for life of parasites. Since September 2011 the “50 Helminth Genomes Project” is running, but from a large group of Monogenea only one species is currently sequenced - Protopolystoma xenopodis. We would like to change this situation and therefore we adopted Eudiplozoon nipponicum (Monogenea: Diplozoidae) as a model organism and started some preliminary analyses leaded to generation of E. nipponicum genome, transcriptome and proteome databases. We would like to use data platforms for identification and further characterization of protein molecules involved into the interaction between host and parasite. Our preliminary transcriptome results suggest that such molecules could be serine peptidases. Serine peptidases are molecules essential for life in all organism including parasitic helminths. These molecules help them to penetrate the defensive barriers and avoid the immune attack of the host. Hematophagous parasites allows digest blood and obtain necessary nutrients.
ER  -

VOREL, Jiří, Hana DVOŘÁKOVÁ, Lucie JEDLIČKOVÁ, Libor MIKEŠ, Milan GELNAR and Martin KAŠNÝ. The bioinformatic analyses of “-omes” of helminths with special focus on serine peptidases of Eudiplozoon nipponicum. In \textit{21st Helminthological Days}. 2014. ISBN~978-80-210-6796-7.

Detailed Information on Publication Record