Neurobiology of ADHD From Childhood to Adulthood: Findings of
Imaging Methods

J 2015

Neurobiology of ADHD From Childhood to Adulthood: Findings of Imaging Methods

KAŠPÁREK, Tomáš, Pavel THEINER and Alena FILOVA

Basic information

Original name

Neurobiology of ADHD From Childhood to Adulthood: Findings of Imaging Methods

Authors

KAŠPÁREK, Tomáš (203 Czech Republic, guarantor, belonging to the institution), Pavel THEINER (203 Czech Republic, belonging to the institution) and Alena FILOVA (203 Czech Republic)

Edition

Journal of Attention Disorders, Thousand Oaks, Sage Publication, 2015, 1087-0547

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.384

RIV identification code

RIV/00216224:14110/15:00087451

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1177/1087054713505322

UT WoS

000362596600003

Keywords in English

ADD/ADHD; Neurobiology; Neuroimaging

Abstract

V originále

Objective: To review the pattern of morphological and functional brain changes in both children and adults with ADHD that emerges from the recent literature. In addition, the task of the present review is to explore how to understand the nature of the brain changes. Methods: Literature review. Results: Neuroimaging studies provide a multitude of information that currently allows us to expand the notions of ADHD neurobiology beyond its traditional understanding as a manifestation of frontostriatal dysfunction. They point to disorders of several other areas of the brain, particularly the anterior cingulum, the dorsolateral as well as ventrolateral prefrontal cortex, the orbitofrontal cortex, the superior parietal regions, the caudate nucleus, the thalamus, the amygdala and the cerebellum. Imaging studies point to the persistence of changes in both brain structure and function into adulthood, although there might be a tendency for improvement of caudate nucleus pathology. Changes in neuronal (dendritic) plasticity, which are under the modulatory influence of the dopaminergic system, may be in the background of disorders of brain morphology and anatomical connectivity with subsequent brain dysfunction. Growing evidence suggest that methylphenidate treatment can lead to improvement of brain changes seen in neuroimaging by its positive effect on neuroplasticity. Conclusion: Changes in neuronal plasticity may be behind persisting brain changes in ADHD. Current treatment approaches seem to improve these neuroplastic processes, and, therefore, may have a positive effect on the neuropathology of ADHD.

Links

NT13437, research and development project

Name: Mozeček, kognitivní dysfunkce a mechanismy kontroly pohybu a odhadu času u dystonie a schizofrenie.

Citovat

KAŠPÁREK, Tomáš, Pavel THEINER and Alena FILOVA. Neurobiology of ADHD From Childhood to Adulthood: Findings of Imaging Methods. Journal of Attention Disorders. Thousand Oaks: Sage Publication, 2015, vol. 19, No 11, p. 931-943. ISSN 1087-0547. Available from: https://dx.doi.org/10.1177/1087054713505322.

@article{1314391,
   author = {Kašpárek, Tomáš and Theiner, Pavel and Filova, Alena},
   article_location = {Thousand Oaks},
   article_number = {11},
   doi = {http://dx.doi.org/10.1177/1087054713505322},
   keywords = {ADD/ADHD; Neurobiology; Neuroimaging},
   language = {eng},
   issn = {1087-0547},
   journal = {Journal of Attention Disorders},
   title = {Neurobiology of ADHD From Childhood to Adulthood: Findings of Imaging Methods},
   volume = {19},
   year = {2015}
}

TY  - JOUR
ID  - 1314391
AU  - Kašpárek, Tomáš - Theiner, Pavel - Filova, Alena
PY  - 2015
TI  - Neurobiology of ADHD From Childhood to Adulthood: Findings of Imaging Methods
JF  - Journal of Attention Disorders
VL  - 19
IS  - 11
SP  - 931-943
EP  - 931-943
PB  - Sage Publication
SN  - 10870547
KW  - ADD/ADHD
KW  - Neurobiology
KW  - Neuroimaging
N2  - Objective: To review the pattern of morphological and functional brain changes in both children and adults with ADHD that emerges from the recent literature. In addition, the task of the present review is to explore how to understand the nature of the brain changes. Methods: Literature review. Results: Neuroimaging studies provide a multitude of information that currently allows us to expand the notions of ADHD neurobiology beyond its traditional understanding as a manifestation of frontostriatal dysfunction. They point to disorders of several other areas of the brain, particularly the anterior cingulum, the dorsolateral as well as ventrolateral prefrontal cortex, the orbitofrontal cortex, the superior parietal regions, the caudate nucleus, the thalamus, the amygdala and the cerebellum. Imaging studies point to the persistence of changes in both brain structure and function into adulthood, although there might be a tendency for improvement of caudate nucleus pathology. Changes in neuronal (dendritic) plasticity, which are under the modulatory influence of the dopaminergic system, may be in the background of disorders of brain morphology and anatomical connectivity with subsequent brain dysfunction. Growing evidence suggest that methylphenidate treatment can lead to improvement of brain changes seen in neuroimaging by its positive effect on neuroplasticity. Conclusion: Changes in neuronal plasticity may be behind persisting brain changes in ADHD. Current treatment approaches seem to improve these neuroplastic processes, and, therefore, may have a positive effect on the neuropathology of ADHD.
ER  -

KAŠPÁREK, Tomáš, Pavel THEINER and Alena FILOVA. Neurobiology of ADHD From Childhood to Adulthood: Findings of Imaging Methods. \textit{Journal of Attention Disorders}. Thousand Oaks: Sage Publication, 2015, vol.~19, No~11, p.~931-943. ISSN~1087-0547. Available from: https://dx.doi.org/10.1177/1087054713505322.

Detailed Information on Publication Record