HYRŠL, Pavel, Pavel DOBEŠ, Badrul AREFIN, Jakub BERKA, Lucie KUČEROVÁ, Robert MARKUS, Zhi WANG, Michal ŽUROVEC and Ulrich THEOPOLD. Insect immunity after invasion of entomopathogenic nematodes. In Workshop: At the crossroads between insect immunology, physiology and ecology. 2015.
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Basic information
Original name Insect immunity after invasion of entomopathogenic nematodes
Name in Czech Insect immunity after invasion of entomopathogenic nematodes
Authors HYRŠL, Pavel (203 Czech Republic, guarantor, belonging to the institution), Pavel DOBEŠ (203 Czech Republic, belonging to the institution), Badrul AREFIN (752 Sweden), Jakub BERKA (203 Czech Republic, belonging to the institution), Lucie KUČEROVÁ (752 Sweden), Robert MARKUS (752 Sweden), Zhi WANG (752 Sweden), Michal ŽUROVEC (203 Czech Republic) and Ulrich THEOPOLD (752 Sweden).
Edition Workshop: At the crossroads between insect immunology, physiology and ecology, 2015.
Other information
Original language English
Type of outcome Conference abstract
Field of Study 30102 Immunology
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14310/15:00080483
Organization unit Faculty of Science
Keywords (in Czech) imunita; Drosophila; hmyz
Keywords in English immunity; Drosophila; insect
Changed by Changed by: doc. RNDr. Pavel Hyršl, Ph.D., učo 9982. Changed: 19/10/2015 18:32.
Abstract
Entomopathogenic nematodes and their associated bacteria comprise together highly pathogenic complex able to invade and kill insect host within two days. Both bacteria and nematodes produce variety of factors interacting with insect immune system that help to overcome host defences. The tripartite model (Drosophila, nematodes, bacteria) was established and used to show an immune function for candidate genes using different Drosophila mutants or RNAi lines with defects in clotting or other branches of the immune system. We demonstrated an immune function during nematode infection for known clotting enzymes and substrates, recognition molecules, eicosanoids etc. In conclusion, we show that the Heterorhabditis/Photorhabdus infection model is suitable to identify novel regulators of innate immunity and we bring evidence of coagulation immune function in insects against nematode infection. Our research is supported by research grants from the Swedish Foundation for International Cooperation in Research and Higher Education (STINT) and by grant from Ministry of Agriculture of Czech Republic (NAZV-KUS QJ1210047).
Abstract (in Czech)
Entomopathogenic nematodes and their associated bacteria comprise together highly pathogenic complex able to invade and kill insect host within two days. Both bacteria and nematodes produce variety of factors interacting with insect immune system that help to overcome host defences. The tripartite model (Drosophila, nematodes, bacteria) was established and used to show an immune function for candidate genes using different Drosophila mutants or RNAi lines with defects in clotting or other branches of the immune system. We demonstrated an immune function during nematode infection for known clotting enzymes and substrates, recognition molecules, eicosanoids etc. In conclusion, we show that the Heterorhabditis/Photorhabdus infection model is suitable to identify novel regulators of innate immunity and we bring evidence of coagulation immune function in insects against nematode infection. Our research is supported by research grants from the Swedish Foundation for International Cooperation in Research and Higher Education (STINT) and by grant from Ministry of Agriculture of Czech Republic (NAZV-KUS QJ1210047).
Links
QJ1210047, research and development projectName: Vývoj nových prostředků pro podporu imunity včel, prevenci a léčbu včelích onemocnění (Acronym: Probiotika - imunita včel)
Investor: Ministry of Agriculture of the CR
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