CIHALOVA, Kristyna, Dagmar CHUDOBOVA, Petr MICHÁLEK, Amitava MOULICK, Roman GURÁŇ, Pavel KOPEL, Vojtěch ADAM and René KIZEK. Staphylococcus aureus and MRSA Growth and Biofilm Formation after Treatment with Antibiotics and SeNPs. International Journal of Molecular Sciences. Molecular Diversity Preservation International, 2015, vol. 16, No 10, p. 24656-24672. ISSN 1661-6596. doi:10.3390/ijms161024656.
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Basic information
Original name Staphylococcus aureus and MRSA Growth and Biofilm Formation after Treatment with Antibiotics and SeNPs
Authors CIHALOVA, Kristyna, Dagmar CHUDOBOVA, Petr MICHÁLEK, Amitava MOULICK, Roman GURÁŇ, Pavel KOPEL, Vojtěch ADAM and René KIZEK.
Edition International Journal of Molecular Sciences, Molecular Diversity Preservation International, 2015, 1661-6596.
Other information
Original language English
Type of outcome Article in a journal
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 2.598 in 2011
Doi http://dx.doi.org/10.3390/ijms161024656
Keywords in English Staphylococcus aureus; MRSA; antibiotics; selenium nanoparticles
Tags International impact, Reviewed
Changed by Changed by: Mgr. Roman Guráň, učo 270205. Changed: 21. 10. 2015 20:31.
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) is a dangerous pathogen resistant to β-lactam antibiotics. Due to its resistance, it is difficult to manage the infections caused by this strain. We examined this issue in terms of observation of the growth properties and ability to form biofilms in sensitive S. aureus and MRSA after the application of antibiotics (ATBs)—ampicillin, oxacillin and penicillin—and complexes of selenium nanoparticles (SeNPs) with these ATBs. The results suggest the strong inhibition effect of SeNPs in complexes with conventional ATBs. Using the impedance method, a higher disruption of biofilms was observed after the application of ATB complexes with SeNPs compared to the group exposed to ATBs without SeNPs. The biofilm formation was intensely inhibited (up to 99% ± 7% for S. aureus and up to 94% ± 4% for MRSA) after application of SeNPs in comparison with bacteria without antibacterial compounds whereas ATBs without SeNPs inhibited S. aureus up to 79% ± 5% and MRSA up to 16% ± 2% only. The obtained results provide a basis for the use of SeNPs as a tool for the treatment of bacterial infections, which can be complicated because of increasing resistance of bacteria to conventional ATB drugs.
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