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@article{1314721,
author = {Babinská, Zuzana and Rudá, Jana and Amchová, Petra and Merhautová, Jana and Dušek, Ladislav and Šulcová, Alexandra},
article_location = {Amsterdam},
article_number = {"neuvedeno"},
doi = {http://dx.doi.org/10.1016/j.bbr.2015.09.035},
keywords = {Sprague-Dawley rats; depression; methamphetamine; olfactory bulbectomy; reinstatement; self-administration},
language = {eng},
issn = {0166-4328},
journal = {Behavioural Brain Research},
title = {Olfactory bulbectomy increases reinstatement of methamphetamine seeking after a forced abstinence in rats},
url = {https://www.sciencedirect.com/science/article/pii/S0166432815302072?via%3Dihub},
volume = {297},
year = {2016}
}
TY - JOUR
ID - 1314721
AU - Babinská, Zuzana - Rudá, Jana - Amchová, Petra - Merhautová, Jana - Dušek, Ladislav - Šulcová, Alexandra
PY - 2016
TI - Olfactory bulbectomy increases reinstatement of methamphetamine seeking after a forced abstinence in rats
JF - Behavioural Brain Research
VL - 297
IS - "neuvedeno"
SP - 20-27
EP - 20-27
PB - Elsevier Science BV
SN - 01664328
KW - Sprague-Dawley rats
KW - depression
KW - methamphetamine
KW - olfactory bulbectomy
KW - reinstatement
KW - self-administration
UR - https://www.sciencedirect.com/science/article/pii/S0166432815302072?via%3Dihub
N2 - Drug addiction is commonly associated with depression and comorbid patients also suffer from higher cravings and increased relapse rate. To address this issue preclinically we combined the olfactory bulbectomy (OBX) model of depression and intravenous methamphetamine self-administration procedure in rats to assess differences in relapse-like behavior. Male Sprague-Dawley rats were divided randomly into two groups; in one group the bilateral olfactory bulbectomy (OBX) was performed while the other group was sham operated. After recovery, intracardiac catheter was implanted. Intravenous self-administration procedure was conducted in operant boxes using nose-poke operandi (Coulbourn Instruments, Inc., USA) under fixed ratio 1 schedule of reinforcement. Methamphetamine was available at dose 0.08 mg/kg/infusion. After stable methamphetamine intake was maintained, a period of forced abstinence was initiated and rats were kept in their home-cages for 14 days. Finally, one reinstatement session was conducted in operant boxes with no drug delivery. In the reinstatement session the mean of 138.4 active nose-pokes was performed by the OBX group, while the sham group displayed 41 responses, i.e. 140 % and 48 % of basal nose-poking during maintenance phase in OBX and sham operated group respectively. OBX group also showed significantly more passive nose-pokes indicating hyperactive behavioral traits in bulbectomized rats. However, the % of active operandum preference was equal in both groups. Olfactory bulbectomy model significantly increased reinstatement of methamphetamine seeking behavior. This paradigm can be used to evaluate potential drugs that are able to suppress the drug-seeking behavior.
ER -
BABINSKÁ, Zuzana, Jana RUDÁ, Petra AMCHOVÁ, Jana MERHAUTOVÁ, Ladislav DUŠEK and Alexandra ŠULCOVÁ. Olfactory bulbectomy increases reinstatement of methamphetamine seeking after a forced abstinence in rats. \textit{Behavioural Brain Research}. Amsterdam: Elsevier Science BV, 2016, vol.~297, ''neuvedeno'', p.~20-27. ISSN~0166-4328. Available from: https://dx.doi.org/10.1016/j.bbr.2015.09.035.
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