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@article{1314821,
author = {Novák, Jan and Olejníčková, Veronika and Tkáčová, Nikola and Santulli, Gaetano},
article_location = {New York},
article_number = {"neuvedeno"},
doi = {http://dx.doi.org/10.1007/978-3-319-22380-3_5},
keywords = {lipid metabolism; HDL; LDL; cholesterol; atherosclerosis; miR-33; miR-122; miR-223},
language = {eng},
issn = {0065-2598},
journal = {Advances in Experimental Medicine and Biology},
title = {Mechanistic Role of MicroRNAs in Coupling Lipid Metabolism and Atherosclerosis},
volume = {887},
year = {2015}
}
TY - JOUR
ID - 1314821
AU - Novák, Jan - Olejníčková, Veronika - Tkáčová, Nikola - Santulli, Gaetano
PY - 2015
TI - Mechanistic Role of MicroRNAs in Coupling Lipid Metabolism and Atherosclerosis
JF - Advances in Experimental Medicine and Biology
VL - 887
IS - "neuvedeno"
SP - 79-100
EP - 79-100
PB - Springer
SN - 00652598
KW - lipid metabolism
KW - HDL
KW - LDL
KW - cholesterol
KW - atherosclerosis
KW - miR-33
KW - miR-122
KW - miR-223
N2 - MicroRNAs (miRNAs, miRs) represent a group of powerful and versatile posttranscriptional regulators of gene expression being involved in the fine control of a plethora of physiological and pathological processes. Besides their well-established crucial roles in the regulation of cell cycle, embryogenesis or tumorigenesis, these tiny molecules have also been shown to participate in the regulation of lipid metabolism. In particular, miRs orchestrate cholesterol and fatty acids synthesis, transport, and degradation and low-density and high-density lipoprotein (LDL and HDL) formation. It is thus not surprising that they have also been reported to affect the development and progression of several lipid metabolism-related disorders including liver steatosis and atherosclerosis. Mounting evidence suggests that miRs might represent important “posttranscriptional hubs” of lipid metabolism, which means that one miR usually targets 3’-untranslated regions of various mRNAs that are involved in different steps of one precise metabolic/signaling pathway, e.g., one miR targets mRNAs of enzymes important for cholesterol synthesis, degradation, and transport. Therefore, changes in the levels of one key miR affect various steps of one pathway, which is thereby promoted or inhibited. This makes miRs potent future diagnostic and even therapeutic tools for personalized medicine. Within this chapter, the most prominent microRNAs involved in lipid metabolism, e.g., miR-27a/b, miR-33/33*, miR-122, miR-144, or miR-223, and their intracellular and extracellular functions will be extensively discussed, in particular focusing on their mechanistic role in the pathophysiology of atherosclerosis. Special emphasis will be given on miR-122, the first microRNA currently in clinical trials for the treatment of hepatitis C and on miR-223, the most abundant miR in lipoprotein particles.
ER -
NOVÁK, Jan, Veronika OLEJNÍČKOVÁ, Nikola TKÁČOVÁ and Gaetano SANTULLI. Mechanistic Role of MicroRNAs in Coupling Lipid Metabolism and Atherosclerosis. \textit{Advances in Experimental Medicine and Biology}. New York: Springer, 2015, vol.~887, ''neuvedeno'', p.~79-100. ISSN~0065-2598. Available from: https://dx.doi.org/10.1007/978-3-319-22380-3\_{}5.
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