VESELÝ, Branislav and Ivan REKTOR. The contribution of white matter lesions (WML) to Parkinson's disease cognitive impairment symptoms: A critical review of the literature. PARKINSONISM & RELATED DISORDERS. OXFORD: ELSEVIER SCI LTD, vol. 22, Supplement 1, p. "S166"-"S170", 5 pp. ISSN 1353-8020. doi:10.1016/j.parkreldis.2015.09.019. 2016.
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Basic information
Original name The contribution of white matter lesions (WML) to Parkinson's disease cognitive impairment symptoms: A critical review of the literature
Authors VESELÝ, Branislav (703 Slovakia) and Ivan REKTOR (203 Czech Republic, guarantor, belonging to the institution).
Edition PARKINSONISM & RELATED DISORDERS, OXFORD, ELSEVIER SCI LTD, 2016, 1353-8020.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 4.484
RIV identification code RIV/00216224:14740/16:00089147
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1016/j.parkreldis.2015.09.019
UT WoS 000366781900036
Keywords in English White matter lesions; Cerebrovascular disease; Parkinson's disease; Mild cognitive impairment; Dementia
Tags rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Eva Špillingová, učo 110713. Changed: 31/8/2016 16:21.
Abstract
We reviewed the impact of white matter lesions (WML) of cerebrovascular origin on cognitive impairment in Parkinson's disease (PD) patients. A search of PUBMED and Googlescholar.com revealed eleven studies that met the inclusion criteria: diagnosis based on the United Kingdom Brain Bank criteria (UK BBC); cognitive assessment; WML assessed on magnetic resonance imaging (MRI) by semiquantitative visual scales or automated method. Eight studies described the negative impact of WML on cognition in PD. Patients with mild cognitive impairment (MCI) and dementia had significantly more WML than the group without MCI and dementia. There was significant relationship between increasing total WML volume and worse performance on executive function, memory and language. Patients with vascular parkinsonism and dopaminergic denervation had more severe frontal lobe dysfunctions than patients with PD. In contrast in three studies there was no negative correlation between WML and cognition. Although the progression of neurodegenerative process in advanced stage of PD has been recognized as being mainly responsible for cognitive impairment in PD, WML may also be a contributing factor. It is possible that by reducing the vascular risk factors that cause WML cognitive impairment could be prevented or slowed down. (C) 2015 Elsevier Ltd. All rights reserved.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
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