Detailed Information on Publication Record
2016
The contribution of white matter lesions to Parkinson's disease motor and gait symptoms: a critical review of the literature
VESELÝ, Branislav, Antonini ANGELO and Ivan REKTORBasic information
Original name
The contribution of white matter lesions to Parkinson's disease motor and gait symptoms: a critical review of the literature
Authors
VESELÝ, Branislav (703 Slovakia), Antonini ANGELO (380 Italy) and Ivan REKTOR (203 Czech Republic, guarantor, belonging to the institution)
Edition
Journal of Neural Transmission, Wien, SPRINGER WIEN, 2016, 0300-9564
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30000 3. Medical and Health Sciences
Country of publisher
Austria
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 2.392
RIV identification code
RIV/00216224:14740/16:00089148
Organization unit
Central European Institute of Technology
UT WoS
000373162900010
Keywords in English
White matter lesions; Cerebrovascular disease; Parkinson's disease; Magnetic resonance imaging
Tags
International impact, Reviewed
Změněno: 9/1/2017 09:44, Mgr. Eva Špillingová
Abstract
V originále
White matter lesions (WML) associated with cerebrovascular disease (CVD) may be observed on magnetic resonance imaging in Parkinson's disease (PD) patients. WML are an important factor contributing to postural, gait, and cognitive impairment in the elderly without PD and worsening the course of Alzheimer's disease (AD). Numerous articles are available on this topic. Whether WML modify and negatively influence the clinical symptoms, and course of PD is a subject of debate. The aim of this review is to examine the available literature on the contribution of WML to PD motor symptoms in relation to clinical characteristics and methods of assessing WML on MRI. After reviewing the database, we identified 19 studies reporting the relationship between WML and PD; ten studies focusing on the impact of WML on the cognitive status in PD were excluded. We analysed altogether nine studies reporting the relationship between WML and motor signs of PD. The review found association between WML severity and freezing of gait, less significant to responsiveness to dopaminergic treatment and postural instability; no negative impact on tremor and falls was observed. The impact of WML on bradykinesia and rigidity was inconsistent. Comorbid WML is associated with worsening axial motor performance, probably independently from the degree of nigrostriatal dopaminergic denervation in PD. Reducing the vascular risk factors that cause WML may be helpful in preventing the development of axial symptoms and ultimately in improving the quality of life of patients with PD. Given the lack of systematic studies, additional research in this field is needed.