Acetaldehyde at Clinically Relevant Concentrations Inhibits
Inward Rectifier Potassium Current I-K1 in Rat Ventricular
Myocytes

J 2015

Acetaldehyde at Clinically Relevant Concentrations Inhibits Inward Rectifier Potassium Current I-K1 in Rat Ventricular Myocytes

BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Milena ŠIMURDOVÁ and Jiří ŠIMURDA

Basic information

Original name

Acetaldehyde at Clinically Relevant Concentrations Inhibits Inward Rectifier Potassium Current I-K1 in Rat Ventricular Myocytes

Authors

BÉBAROVÁ, Markéta (203 Czech Republic, guarantor, belonging to the institution), Peter MATEJOVIČ (703 Slovakia, belonging to the institution), Milena ŠIMURDOVÁ (203 Czech Republic, belonging to the institution) and Jiří ŠIMURDA (203 Czech Republic, belonging to the institution)

Edition

Physiological Research, Praha, Fyziologický ústav AV ČR, 2015, 0862-8408

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.643

RIV identification code

RIV/00216224:14110/15:00087452

Organization unit

Faculty of Medicine

UT WoS

000367547900016

Keywords in English

Acetaldehyde; Arrhythmias; Inward rectifier; IK1 inhibition; Rat ventricular myocytes

Abstract

V originále

Considering the effects of alcohol on cardiac electrical behaviour as well as the important role of the inward rectifier potassium current IK1 in arrhythmogenesis, this study was aimed at the effect of acetaldehyde, the primary metabolite of ethanol, on IK1 in rat ventricular myocytes. Acetaldehyde induced a reversible inhibition of IK1 with IC50 = 53.7 +/- 7.7 microM at -110 mV; a significant inhibition was documented even at clinically-relevant concentrations (at 3 microM by 13.1 +/- 3.0%). The inhibition was voltage-independent at physiological voltages above -90 mV. The IK1 changes under acetaldehyde may contribute to alcohol-induced alterations of cardiac electrophysiology, especially in individuals with a genetic defect of aldehyde dehydrogenase where the acetaldehyde level may be elevated.

Links

NT14301, research and development project

Name: Vliv ethanolu a jeho metabolitu acetaldehydu na srdeční inward rectifier draslíkové proudy: vztah k fibrilaci síní po konzumaci alkoholu?

Investor: Ministry of Health of the CR

Citovat

BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Acetaldehyde at Clinically Relevant Concentrations Inhibits Inward Rectifier Potassium Current I-K1 in Rat Ventricular Myocytes. Physiological Research. Praha: Fyziologický ústav AV ČR, 2015, vol. 64, No 6, p. 939-943. ISSN 0862-8408.

@article{1315970,
   author = {Bébarová, Markéta and Matejovič, Peter and Šimurdová, Milena and Šimurda, Jiří},
   article_location = {Praha},
   article_number = {6},
   keywords = {Acetaldehyde; Arrhythmias; Inward rectifier; IK1 inhibition; Rat ventricular myocytes},
   language = {eng},
   issn = {0862-8408},
   journal = {Physiological Research},
   title = {Acetaldehyde at Clinically Relevant Concentrations Inhibits Inward Rectifier Potassium Current I-K1 in Rat Ventricular Myocytes},
   volume = {64},
   year = {2015}
}

TY  - JOUR
ID  - 1315970
AU  - Bébarová, Markéta - Matejovič, Peter - Šimurdová, Milena - Šimurda, Jiří
PY  - 2015
TI  - Acetaldehyde at Clinically Relevant Concentrations Inhibits Inward Rectifier Potassium Current I-K1 in Rat Ventricular Myocytes
JF  - Physiological Research
VL  - 64
IS  - 6
SP  - 939-943
EP  - 939-943
PB  - Fyziologický ústav AV ČR
SN  - 08628408
KW  - Acetaldehyde
KW  - Arrhythmias
KW  - Inward rectifier
KW  - IK1 inhibition
KW  - Rat ventricular myocytes
N2  - Considering the effects of alcohol on cardiac electrical behaviour as well as the important role of the inward rectifier potassium current IK1 in arrhythmogenesis, this study was aimed at the effect of acetaldehyde, the primary metabolite of ethanol, on IK1 in rat ventricular myocytes. Acetaldehyde induced a reversible inhibition of IK1 with IC50 = 53.7 +/- 7.7 microM at -110 mV; a significant inhibition was documented even at clinically-relevant concentrations (at 3 microM by 13.1 +/- 3.0%). The inhibition was voltage-independent at physiological voltages above -90 mV. The IK1 changes under acetaldehyde may contribute to alcohol-induced alterations of cardiac electrophysiology, especially in individuals with a genetic defect of aldehyde dehydrogenase where the acetaldehyde level may be elevated.
ER  -

BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Acetaldehyde at Clinically Relevant Concentrations Inhibits Inward Rectifier Potassium Current I-K1 in Rat Ventricular Myocytes. \textit{Physiological Research}. Praha: Fyziologický ústav AV ČR, 2015, vol.~64, No~6, p.~939-943. ISSN~0862-8408.

Detailed Information on Publication Record