The role of TROP-2 in proliferation, survival and clonogenity
of breast cancer cells

a 2015

The role of TROP-2 in proliferation, survival and clonogenity of breast cancer cells

NEHYBOVÁ, Tereza, Petr BENEŠ, Lucia KNOPFOVÁ, Ján REMŠÍK, Radek FEDR et. al.

Basic information

Original name

The role of TROP-2 in proliferation, survival and clonogenity of breast cancer cells

Name (in English)

The role of TROP-2 in proliferation, survival and clonogenity of breast cancer cells

Authors

NEHYBOVÁ, Tereza, Petr BENEŠ, Lucia KNOPFOVÁ, Ján REMŠÍK, Radek FEDR, Karel SOUČEK and Jan ŠMARDA

Edition

20th World Congress on Advances in Oncology and 18th International Symposium on Molecular Medicine, 2015

Other information

Type of outcome

Konferenční abstrakt

Confidentiality degree

není předmětem státního či obchodního tajemství

Změněno: 9/11/2015 07:44, Mgr. Tereza Kučírková, Ph.D.

Abstract

V originále

Trop-2 is a cell surface transmembrane glycoprotein encoded by the intronless TACSTD2 gene. It is an intracellular calcium signal transducer that has been first identified as an biomarker for trofoblast cells, invasive cells from blastocyst. Trop-2 has multifaceted role during development and tumorigenesis, including regulation cell proliferation, migration, self-renewal and maintenance of basement membrane integrity. Increased expression of Trop-2 was associated with poor prognosis and metastasis in many cancer types but the data remain controversial. While in the lung adenocarcinoma and squamous cell carcinoma, a negative correlation between Trop-2 expression and metastasis/prognosis was observed, the opposite finding has been frequently reported in other epithelial cancers including prostate, colon, ovarian, gastric and breast. These controversial observations are paralleled by studies in various cancer cell line models suggesting a context-dependent function of Trop-2 during tumorigenesis. The main objective of this study was to analyze the molecular basis of Trop-2 expression, signalling and function in breast cancer cells under various conditions of tumor-like microenvironment. We found that Trop-2 affects proliferation, clonogenic capacity and survival of breast cancer cells. Moreover, we identified JNK/AP-1 signaling as an important regulator of Trop2 expression/function in these cells as well. We believe that understanding the mechanisms underlying Trop-2 function in tumor development and progression may further support the use of Trop-2 as prognostic marker and therapeutic target in solid tumors.

Links

NT13441, research and development project

Name: Exprese proteinů rodiny Myb v adenokarcinomech tlustého střeva a vztah k jejich metastatickému potenciálu

Citovat

NEHYBOVÁ, Tereza, Petr BENEŠ, Lucia KNOPFOVÁ, Ján REMŠÍK, Radek FEDR, Karel SOUČEK and Jan ŠMARDA. The role of TROP-2 in proliferation, survival and clonogenity of breast cancer cells. In 20th World Congress on Advances in Oncology and 18th International Symposium on Molecular Medicine. 2015.

@proceedings{1316701,
   author = {Nehybová, Tereza and Beneš, Petr and Knopfová, Lucia and Remšík, Ján and Fedr, Radek and Souček, Karel and Šmarda, Jan},
   booktitle = {20th World Congress on Advances in Oncology and 18th International Symposium on Molecular Medicine},
   title = {The role of TROP-2 in proliferation, survival and clonogenity of breast cancer cells},
   year = {2015}
}

TY  - CONF
ID  - 1316701
AU  - Nehybová, Tereza - Beneš, Petr - Knopfová, Lucia - Remšík, Ján - Fedr, Radek - Souček, Karel - Šmarda, Jan
PY  - 2015
TI  - The role of TROP-2 in proliferation, survival and clonogenity of breast cancer cells
N2  - Trop-2 is a cell surface transmembrane glycoprotein encoded by the intronless TACSTD2 gene. It is an intracellular calcium signal transducer that has been first identified as an biomarker for trofoblast cells, invasive cells from blastocyst. Trop-2 has multifaceted role during development and tumorigenesis, including regulation cell proliferation, migration, self-renewal and maintenance of basement membrane integrity. Increased expression of Trop-2 was associated with poor prognosis and metastasis in many cancer types but the data remain controversial. While in the lung adenocarcinoma and squamous cell carcinoma, a negative correlation between Trop-2 expression and metastasis/prognosis was observed, the opposite finding has been frequently reported in other epithelial cancers including prostate, colon, ovarian, gastric and breast. These controversial observations are paralleled by studies in various cancer cell line models suggesting a context-dependent function of Trop-2 during tumorigenesis. The main objective of this study was to analyze the molecular basis of Trop-2 expression, signalling and function in breast cancer cells under various conditions of tumor-like microenvironment. We found that Trop-2 affects proliferation, clonogenic capacity and survival of breast cancer cells. Moreover, we identified JNK/AP-1 signaling as an important regulator of Trop2 expression/function in these cells as well. We believe that understanding the mechanisms underlying Trop-2 function in tumor development and progression may further support the use of Trop-2 as prognostic marker and therapeutic target in solid tumors.
ER  -

NEHYBOVÁ, Tereza, Petr BENEŠ, Lucia KNOPFOVÁ, Ján REMŠÍK, Radek FEDR, Karel SOUČEK and Jan ŠMARDA. The role of TROP-2 in proliferation, survival and clonogenity of breast cancer cells. In \textit{20th World Congress on Advances in Oncology and 18th International Symposium on Molecular Medicine}. 2015.

Detailed Information on Publication Record