| HEGER, Z., Jimenez A. JIMENEZ, B. RUTTKAY-NEDECKY, M. KOMINKOVA, L. RICHTERA, Michal MASAŘÍK, O. ZITKA, Hana BINKOVÁ, V. ADAM and R. KIZEK. RELATION BETWEEN HPV STATUS AND OXIDATIVE STRESS INDICATORS IN PATIENTS WITH HEAD AND NECK CANCER. In 30th International Papillomavirus Conference & Clinical Workshop (HPV 2015). 2015. |
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@proceedings{1317016,
author = {Heger, Z. and Jimenez, Jimenez A. and RuttkayandNedecky, B. and Kominkova, M. and Richtera, L. and Masařík, Michal and Zitka, O. and Binková, Hana and Adam, V. and Kizek, R.},
booktitle = {30th International Papillomavirus Conference & Clinical Workshop (HPV 2015)},
keywords = {HPV status; head cancer; neck cancer},
language = {eng},
title = {RELATION BETWEEN HPV STATUS AND OXIDATIVE STRESS INDICATORS IN PATIENTS WITH HEAD AND NECK CANCER},
year = {2015}
}
TY - CONF
ID - 1317016
AU - Heger, Z. - Jimenez, Jimenez A. - Ruttkay-Nedecky, B. - Kominkova, M. - Richtera, L. - Masařík, Michal - Zitka, O. - Binková, Hana - Adam, V. - Kizek, R.
PY - 2015
TI - RELATION BETWEEN HPV STATUS AND OXIDATIVE STRESS INDICATORS IN PATIENTS WITH HEAD AND NECK CANCER
KW - HPV status
KW - head cancer
KW - neck cancer
N2 - OBJECTIVES Only a minority of HPV infections lead to invasive neoplastic state, indicating that viral oncogenes expression is not per se sufficient, and other events are required for succesfull oncogenesis. Presented study determines whether the HPV status in head and neck cancer (HNC) patients corresponds to biochemical markers of oxidative stress - metallothionein and reduced (GSH) and oxidized (GSSG) glutathiones. CONCLUSION Our examination of oxidative stress in HPV positive and negative specimens revealed differences in metallothionein levels. Our findings show that oxidative stress is involved in oncogenesis of HPV and further analyses of production of reactive oxygen species after infection should be performed.
ER -
HEGER, Z., Jimenez A. JIMENEZ, B. RUTTKAY-NEDECKY, M. KOMINKOVA, L. RICHTERA, Michal MASAŘÍK, O. ZITKA, Hana BINKOVÁ, V. ADAM and R. KIZEK. RELATION BETWEEN HPV STATUS AND OXIDATIVE STRESS INDICATORS IN PATIENTS WITH HEAD AND NECK CANCER. In \textit{30th International Papillomavirus Conference \&{} Clinical Workshop (HPV 2015)}. 2015.
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