Detailed Information on Publication Record
2015
The possibilities of endoluminal ablation techniques
ANDRAŠINA, TomášBasic information
Original name
The possibilities of endoluminal ablation techniques
Authors
ANDRAŠINA, Tomáš (703 Slovakia, guarantor, belonging to the institution)
Edition
27th International Conference of the Society for Medical Innovation and Technology, 2015
Other information
Language
English
Type of outcome
Prezentace na konferencích
Field of Study
30000 3. Medical and Health Sciences
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14110/15:00087459
Organization unit
Faculty of Medicine
Keywords in English
endoluminal techniques; ablation radiofrequency; irreversible electroporation; bile ducts
Tags
Změněno: 6/4/2016 14:35, Ing. Mgr. Věra Pospíšilíková
Abstract
V originále
Tumours growing from the epithelium of the biliary tract are most common in the hilar region and the complexity of the perihilar liver region causes curative surgical resection to be very complicated. The resectability and the 5-year survival rate of hilar cholangiocarcinomas are very low. There are many tested chemotherapeutic regimes combining systemic delivery with intra-arterial chemotherapy or chemoembolization, but none of these has yet become the standard therapy. In addition to palliative surgical procedures, endoscopic and percutaneous therapeutic methods of the bile ducts drainage there are several competing techniques and interventions aiming to control of disease - radiation therapies (external beam, intraluminal brachytherapy), photodynamic therapies and endoluminal ablations. More often they are so-called tailored oncological therapies. Local ablation techniques such as endoluminal radiofrequency ablation with simple and one-time application are potentially useful in debulking of the endoluminal tumours, preventing early ingrowth of the tumours through the stent mesh, and even helping to resolve stent obstruction. Another alternative therapeutic intervention in this field is non-thermal ablation method - irreversible electroporation. During electroporation the cells in the tissue are exposed to the short pulses of very high voltages. Pulses of high voltage changes transmembrane electrochemical potential resulting in cell membrane instabilities and disruption of the membrane. The advantage of electroporation to the radiofrequency ablation is the absence of heat damage to healthy tissue, the precise shape and volume of necrosis and this technique also lacks of the heat sink effect. The architecture of the tissue is preserved and reparation along it is possible. Hilar cholangiocarcinoma is a complex medical problem. Survival times can be influenced by optimal drainage, brachytherapy, photodynamic therapy or other ablation treatments.
Links
NT14586, research and development project |
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NV15-32484A, research and development project |
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