Coordination compounds in cancer: Past, present and
perspectives

J 2015

Coordination compounds in cancer: Past, present and perspectives

TRUDU, Federica, Filippo AMATO, Petr VAŇHARA, Tiziana PIVETTA, E. M. PEÑA-MÉNDEZ et. al.

Basic information

Original name

Coordination compounds in cancer: Past, present and perspectives

Authors

TRUDU, Federica (380 Italy, belonging to the institution), Filippo AMATO (380 Italy, belonging to the institution), Petr VAŇHARA (203 Czech Republic, belonging to the institution), Tiziana PIVETTA (380 Italy), E. M. PEÑA-MÉNDEZ (724 Spain) and Josef HAVEL (203 Czech Republic, guarantor, belonging to the institution)

Edition

Journal of applied biomedicine, České Budějovice, Faculty of Health and Social Care, University of South Bohemia, 2015, 1214-021X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.509

RIV identification code

RIV/00216224:14310/15:00084756

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.jab.2015.03.003

UT WoS

000354949400002

Keywords in English

Cancer; Coordination metal complexes; Cisplatin; Omics; Perspectives

Abstract

V originále

Metal-based coordination compounds have been used throughout the history of human medicine to treat various diseases, including cancer. Since the discovery of cisplatin in 1965, a great number of metal coordination complexes, such as platinum, ruthenium, gold or copper have been designed, synthesized and tested in order to develop clinically effective and safe drugs. Currently, many reviews cover applications of cytostatic metal complexes pointing out the most promising examples of platinum- and non-platinum-based compounds in preclinical and clinical trials. However, recent comprehensive reviews covering chemical and biological aspects of metal-based coordination compounds in cancer therapy are still rare. In this review we wish to provide an overview of the coordination chemistry of current and novel cytostatic compounds, including an outline of their design and rationale of synthesis, and summarize bio-chemical reactivity and physicochemical properties of candidate metal complexes.

Links

EE2.3.20.0185, research and development project

Name: Centrum analýz a modelování tkání a orgánů

MUNI/A/1558/2014, interní kód MU

Name: Zdroje pro tkáňové inženýrství 5 (Acronym: TissueEng5)

Investor: Masaryk University, Category A

Citovat

TRUDU, Federica, Filippo AMATO, Petr VAŇHARA, Tiziana PIVETTA, E. M. PEÑA-MÉNDEZ and Josef HAVEL. Coordination compounds in cancer: Past, present and perspectives. Journal of applied biomedicine. České Budějovice: Faculty of Health and Social Care, University of South Bohemia, 2015, vol. 13, No 2, p. 79-103. ISSN 1214-021X. Available from: https://dx.doi.org/10.1016/j.jab.2015.03.003.

@article{1317750,
   author = {Trudu, Federica and Amato, Filippo and Vaňhara, Petr and Pivetta, Tiziana and PeñaandMéndez, E. M. and Havel, Josef},
   article_location = {České Budějovice},
   article_number = {2},
   doi = {http://dx.doi.org/10.1016/j.jab.2015.03.003},
   keywords = {Cancer; Coordination metal complexes; Cisplatin; Omics; Perspectives},
   language = {eng},
   issn = {1214-021X},
   journal = {Journal of applied biomedicine},
   title = {Coordination compounds in cancer: Past, present and perspectives},
   volume = {13},
   year = {2015}
}

TY  - JOUR
ID  - 1317750
AU  - Trudu, Federica - Amato, Filippo - Vaňhara, Petr - Pivetta, Tiziana - Peña-Méndez, E. M. - Havel, Josef
PY  - 2015
TI  - Coordination compounds in cancer: Past, present and perspectives
JF  - Journal of applied biomedicine
VL  - 13
IS  - 2
SP  - 79-103
EP  - 79-103
PB  - Faculty of Health and Social Care, University of South Bohemia
SN  - 1214021X
KW  - Cancer
KW  - Coordination metal complexes
KW  - Cisplatin
KW  - Omics
KW  - Perspectives
N2  - Metal-based coordination compounds have been used throughout the history of human medicine to treat various diseases, including cancer. Since the discovery of cisplatin in 1965, a great number of metal coordination complexes, such as platinum, ruthenium, gold or copper have been designed, synthesized and tested in order to develop clinically effective and safe drugs. Currently, many reviews cover applications of cytostatic metal complexes pointing out the most promising examples of platinum- and non-platinum-based compounds in preclinical and clinical trials. However, recent comprehensive reviews covering chemical and biological aspects of metal-based coordination compounds in cancer therapy are still rare. In this review we wish to provide an overview of the coordination chemistry of current and novel cytostatic compounds, including an outline of their design and rationale of synthesis, and summarize bio-chemical reactivity and physicochemical properties of candidate metal complexes.
ER  -

TRUDU, Federica, Filippo AMATO, Petr VAŇHARA, Tiziana PIVETTA, E. M. PEÑA-MÉNDEZ and Josef HAVEL. Coordination compounds in cancer: Past, present and perspectives. \textit{Journal of applied biomedicine}. České Budějovice: Faculty of Health and Social Care, University of South Bohemia, 2015, vol.~13, No~2, p.~79-103. ISSN~1214-021X. Available from: https://dx.doi.org/10.1016/j.jab.2015.03.003.

Detailed Information on Publication Record