The erratic antibiotic susceptibility patterns of bacterial
pathogens causing urinary tract infections

J 2015

The erratic antibiotic susceptibility patterns of bacterial pathogens causing urinary tract infections

AHMED, Iftkhar, Muhammad SAJED, Aneesa SULTAN, Iram MURTAZA, Sohail YOUSAF et. al.

Basic information

Original name

The erratic antibiotic susceptibility patterns of bacterial pathogens causing urinary tract infections

Authors

AHMED, Iftkhar (586 Pakistan), Muhammad SAJED (586 Pakistan), Aneesa SULTAN (586 Pakistan), Iram MURTAZA (586 Pakistan), Sohail YOUSAF (586 Pakistan), Bushra MAQSOOD (585 Palau), Petr VAŇHARA (203 Czech Republic, guarantor, belonging to the institution) and Mariam ANEES (586 Pakistan)

Edition

EXCLI JOURNAL, DORTMUND, EXCLI JOURNAL MANAGING OFFICE, 2015, 1611-2156

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.292

RIV identification code

RIV/00216224:14110/15:00084872

Organization unit

Faculty of Medicine

UT WoS

000359202800027

Keywords in English

Escherichia coli; Klebsiella pneumoniae; ESBL; antibiotic susceptibility

Abstract

V originále

Increasing trend of antibiotic resistance and expression of Extended Spectrum Beta Lactamases (ESBLs) are serious threats for public health as they render the treatment ineffective. Present study was designed to elucidate the antibiotic-susceptibility patterns of ESBL and non-ESBL producing E. coli and K. pneumoniae causing urinary tract infections so that the ineffective antibiotics could be removed from the line of treatment. The bacterial isolates obtained from the urine of patients visiting a tertiary health care facility were cultured for strain identification using API20E. Antimicrobial susceptibility and ESBL detection were done by Kirby-bauer diffusion technique. Almost 53.4 % isolates of E. coli and 24.5 % isolates of K. pneumoniae were found to be ESBL producers. The ESBL producing bacteria were found to be more resistant towards various antibiotics. The most effective drugs against E. coli ESBL isolates were imipenem (99.54 %), ampicillin-sulbactam (97.48 %), piperacillin-tazobactam (96.86 %), fosfomycin (94.51 %), amikacin (92.26 %) and nitrofurantoin (90.68 %). The most effective drugs against K. pneumoniae ESBL isolates were imipenem (97.62 %), piperacillin-tazobactam (95.35 %), ampicillin-sulbactam (90.48 %) and amikacin (88.37 %). The antibiotics having the highest resistance, particularly by the ESBL producers were amoxicillin clavulanic acid, sulphamethoxalzole/ trimethoprim, cefuroxime, cefpirome, ceftriaxone and ciprofloxacin. Most of the isolates showed multi drug resistance (MDR). High frequency of ESBL producing E. coli and K. pneumoniae were observed as compared to previous data. Penicillins, cephalosporins and some representatives of fluoroquinolones were least effective against the common UTIs and are recommended to be removed from the line of treatment.

Citovat

AHMED, Iftkhar, Muhammad SAJED, Aneesa SULTAN, Iram MURTAZA, Sohail YOUSAF, Bushra MAQSOOD, Petr VAŇHARA and Mariam ANEES. The erratic antibiotic susceptibility patterns of bacterial pathogens causing urinary tract infections. EXCLI JOURNAL. DORTMUND: EXCLI JOURNAL MANAGING OFFICE, 2015, vol. 14, 4 August 2015, p. 916-925. ISSN 1611-2156.

@article{1318620,
   author = {Ahmed, Iftkhar and Sajed, Muhammad and Sultan, Aneesa and Murtaza, Iram and Yousaf, Sohail and Maqsood, Bushra and Vaňhara, Petr and Anees, Mariam},
   article_location = {DORTMUND},
   article_number = {4 August 2015},
   keywords = {Escherichia coli; Klebsiella pneumoniae; ESBL; antibiotic susceptibility},
   language = {eng},
   issn = {1611-2156},
   journal = {EXCLI JOURNAL},
   title = {The erratic antibiotic susceptibility patterns of bacterial pathogens causing urinary tract infections},
   volume = {14},
   year = {2015}
}

TY  - JOUR
ID  - 1318620
AU  - Ahmed, Iftkhar - Sajed, Muhammad - Sultan, Aneesa - Murtaza, Iram - Yousaf, Sohail - Maqsood, Bushra - Vaňhara, Petr - Anees, Mariam
PY  - 2015
TI  - The erratic antibiotic susceptibility patterns of bacterial pathogens causing urinary tract infections
JF  - EXCLI JOURNAL
VL  - 14
IS  - 4 August 2015
SP  - 916-925
EP  - 916-925
PB  - EXCLI JOURNAL MANAGING OFFICE
SN  - 16112156
KW  - Escherichia coli
KW  - Klebsiella pneumoniae
KW  - ESBL
KW  - antibiotic susceptibility
N2  - Increasing trend of antibiotic resistance and expression of Extended Spectrum Beta Lactamases (ESBLs) are serious threats for public health as they render the treatment ineffective. Present study was designed to elucidate the antibiotic-susceptibility patterns of ESBL and non-ESBL producing E. coli and K. pneumoniae causing urinary tract infections so that the ineffective antibiotics could be removed from the line of treatment. The bacterial isolates obtained from the urine of patients visiting a tertiary health care facility were cultured for strain identification using API20E. Antimicrobial susceptibility and ESBL detection were done by Kirby-bauer diffusion technique. Almost 53.4 % isolates of E. coli and 24.5 % isolates of K. pneumoniae were found to be ESBL producers. The ESBL producing bacteria were found to be more resistant towards various antibiotics. The most effective drugs against E. coli ESBL isolates were imipenem (99.54 %), ampicillin-sulbactam (97.48 %), piperacillin-tazobactam (96.86 %), fosfomycin (94.51 %), amikacin (92.26 %) and nitrofurantoin (90.68 %). The most effective drugs against K. pneumoniae ESBL isolates were imipenem (97.62 %), piperacillin-tazobactam (95.35 %), ampicillin-sulbactam (90.48 %) and amikacin (88.37 %). The antibiotics having the highest resistance, particularly by the ESBL producers were amoxicillin clavulanic acid, sulphamethoxalzole/ trimethoprim, cefuroxime, cefpirome, ceftriaxone and ciprofloxacin. Most of the isolates showed multi drug resistance (MDR). High frequency of ESBL producing E. coli and K. pneumoniae were observed as compared to previous data. Penicillins, cephalosporins and some representatives of fluoroquinolones were least effective against the common UTIs and are recommended to be removed from the line of treatment.
ER  -

AHMED, Iftkhar, Muhammad SAJED, Aneesa SULTAN, Iram MURTAZA, Sohail YOUSAF, Bushra MAQSOOD, Petr VAŇHARA and Mariam ANEES. The erratic antibiotic susceptibility patterns of bacterial pathogens causing urinary tract infections. \textit{EXCLI JOURNAL}. DORTMUND: EXCLI JOURNAL MANAGING OFFICE, 2015, vol.~14, 4 August 2015, p.~916-925. ISSN~1611-2156.

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