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@article{1319430, author = {Schubertová, Veronika and MartinezandVeracoechea, Francisco J. and Vácha, Robert}, article_location = {CAMBRIDGE}, article_number = {14}, doi = {http://dx.doi.org/10.1039/c4sm02815e}, keywords = {RECEPTOR-MEDIATED ENDOCYTOSIS; SHAPE ANISOTROPY; LIPID-BILAYER; NANOPARTICLES; MEMBRANE; TRANSLOCATION; ROTATION}, language = {eng}, issn = {1744-683X}, journal = {SOFT MATTER}, title = {Influence of ligand distribution on uptake efficiency}, url = {http://pubs.rsc.org/en/content/articlepdf/2015/sm/c4sm02815e}, volume = {11}, year = {2015} }
TY - JOUR ID - 1319430 AU - Schubertová, Veronika - Martinez-Veracoechea, Francisco J. - Vácha, Robert PY - 2015 TI - Influence of ligand distribution on uptake efficiency JF - SOFT MATTER VL - 11 IS - 14 SP - 2726-2730 EP - 2726-2730 PB - ROYAL SOC CHEMISTRY SN - 1744683X KW - RECEPTOR-MEDIATED ENDOCYTOSIS KW - SHAPE ANISOTROPY KW - LIPID-BILAYER KW - NANOPARTICLES KW - MEMBRANE KW - TRANSLOCATION KW - ROTATION UR - http://pubs.rsc.org/en/content/articlepdf/2015/sm/c4sm02815e L2 - http://pubs.rsc.org/en/content/articlepdf/2015/sm/c4sm02815e N2 - Cellular uptake is a crucial process in nanomedicine and drug-delivery; however, the factors that affect its efficiency/speed are not well understood. We report computer simulations on passive uptake via receptor-mediated endocytosis of nanoparticle coated with ligands. In particular, we study how the distribution of ligands on the nanoparticle surface influences the uptake rate. The speed of membrane wrapping and uptake was found to be the fastest for nanoparticles with homogeneous ligand distributions, where ligands are spread evenly on the surface. We show that the diffusion of the ligands on the nanoparticle can hinder its uptake, since upon the interaction with the membrane the ligand distribution becomes extremely inhomogeneous, with a large ligand-free patch. When the ligand-free-area was more than 20% of the surface, we did not observe uptake within the scale of our simulations. ER -
SCHUBERTOVÁ, Veronika, Francisco J. MARTINEZ-VERACOECHEA a Robert VÁCHA. Influence of ligand distribution on uptake efficiency. \textit{SOFT MATTER}. CAMBRIDGE: ROYAL SOC CHEMISTRY, roč.~11, č.~14, s.~2726-2730. ISSN~1744-683X. doi:10.1039/c4sm02815e. 2015.
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