SCHUBERTOVÁ, Veronika, Francisco J. MARTINEZ-VERACOECHEA and Robert VÁCHA. Influence of ligand distribution on uptake efficiency. SOFT MATTER. CAMBRIDGE: ROYAL SOC CHEMISTRY, 2015, vol. 11, No 14, p. 2726-2730. ISSN 1744-683X. doi:10.1039/c4sm02815e.
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Basic information
Original name Influence of ligand distribution on uptake efficiency
Authors SCHUBERTOVÁ, Veronika (203 Czech Republic, belonging to the institution), Francisco J. MARTINEZ-VERACOECHEA (826 United Kingdom of Great Britain and Northern Ireland) and Robert VÁCHA (203 Czech Republic, guarantor, belonging to the institution).
Edition SOFT MATTER, CAMBRIDGE, ROYAL SOC CHEMISTRY, 2015, 1744-683X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10403 Physical chemistry
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 3.798
RIV identification code RIV/00216224:14740/15:00081252
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1039/c4sm02815e
UT WoS 000351711800003
Keywords in English RECEPTOR-MEDIATED ENDOCYTOSIS; SHAPE ANISOTROPY; LIPID-BILAYER; NANOPARTICLES; MEMBRANE; TRANSLOCATION; ROTATION
Tags OA, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Eva Špillingová, učo 110713. Changed: 4. 4. 2016 13:37.
Abstract
Cellular uptake is a crucial process in nanomedicine and drug-delivery; however, the factors that affect its efficiency/speed are not well understood. We report computer simulations on passive uptake via receptor-mediated endocytosis of nanoparticle coated with ligands. In particular, we study how the distribution of ligands on the nanoparticle surface influences the uptake rate. The speed of membrane wrapping and uptake was found to be the fastest for nanoparticles with homogeneous ligand distributions, where ligands are spread evenly on the surface. We show that the diffusion of the ligands on the nanoparticle can hinder its uptake, since upon the interaction with the membrane the ligand distribution becomes extremely inhomogeneous, with a large ligand-free patch. When the ligand-free-area was more than 20% of the surface, we did not observe uptake within the scale of our simulations.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
GA14-12598S, research and development projectName: Samouspořádané systémy amfifilních peptiů (Acronym: SAAP)
Investor: Czech Science Foundation
286154, interní kód MUName: SYLICA - Synergies of Life and Material Sciences to Create a New Future (Acronym: SYLICA)
Investor: European Union, Capacities
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