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@article{1319527,
author = {Červinek, Libor and Mayer, Jiří and Doubek, Michael},
article_location = {Tokyo},
article_number = {1},
doi = {http://dx.doi.org/10.1007/s12185-015-1793-1},
keywords = {Immune thrombocytopenia; Thrombopoietin-receptor agonists; Remission; Sustained response},
language = {eng},
issn = {0925-5710},
journal = {International journal of hematology},
title = {Sustained remission of chronic immune thrombocytopenia after discontinuation of treatment with thrombopoietin-receptor agonists in adults},
url = {http://download.springer.com/static/pdf/372/art%253A10.1007%252Fs12185-015-1793-1.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs12185-015-1793-1&token2=exp=1448961063~acl=%2Fstatic%2Fpdf%2F372%2Fart%25253A10.1007%25252Fs12185-015-17},
volume = {102},
year = {2015}
}
TY - JOUR
ID - 1319527
AU - Červinek, Libor - Mayer, Jiří - Doubek, Michael
PY - 2015
TI - Sustained remission of chronic immune thrombocytopenia after discontinuation of treatment with thrombopoietin-receptor agonists in adults
JF - International journal of hematology
VL - 102
IS - 1
SP - 7-11
EP - 7-11
PB - Springer Japan KK
SN - 09255710
KW - Immune thrombocytopenia
KW - Thrombopoietin-receptor agonists
KW - Remission
KW - Sustained response
UR - http://download.springer.com/static/pdf/372/art%253A10.1007%252Fs12185-015-1793-1.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs12185-015-1793-1&token2=exp=1448961063~acl=%2Fstatic%2Fpdf%2F372%2Fart%25253A10.1007%25252Fs12185-015-17
L2 - http://download.springer.com/static/pdf/372/art%253A10.1007%252Fs12185-015-1793-1.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs12185-015-1793-1&token2=exp=1448961063~acl=%2Fstatic%2Fpdf%2F372%2Fart%25253A10.1007%25252Fs12185-015-17
N2 - Thrombopoietin-receptor agonists (TPO-RAs) are highly effective in immune thrombocytopenia (ITP). Recently, reports of sustained remission after TPO-RA discontinuation in adult ITP have been reported. We aimed to describe the subset of patients in whom TPO-RA therapy may induce a durable response. We retrospectively analyzed all of our adult ITP patients treated with TPO-RAs, and focused on patients with discontinued TPO-RA therapy due to treatment response. Forty-six relapsed or refractory ITP patients were treated with TPO-RAs. In 11 of these cases, TPO-RA therapy (seven romiplostim; four eltrombopag) was stopped after achieving treatment response. No side effects of TPO-RAs were observed. These patients were pretreated with 1-3 therapy lines plus splenectomy in six patients prior to TPO-RA administration. None of these patients experienced disease relapse after therapy discontinuation over a median follow-up of 33 months (16-54). Substantial proportion of ITP patients receiving TPO-RAs can maintain a durable response after treatment discontinuation. Sustained ITP remission probably does not depend on previous treatment, splenectomy, or disease duration.
ER -
ČERVINEK, Libor, Jiří MAYER and Michael DOUBEK. Sustained remission of chronic immune thrombocytopenia after discontinuation of treatment with thrombopoietin-receptor agonists in adults. \textit{International journal of hematology}. Tokyo: Springer Japan KK, 2015, vol.~102, No~1, p.~7-11. ISSN~0925-5710. doi:10.1007/s12185-015-1793-1.
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