Addenbrooke's Cognitive Examination and Individual Domain Cut-Off Scores for Discriminating between Different Cognitive Subtypes of Parkinson's Disease

BERÁNKOVÁ, Dagmar, Eva JANOUŠOVÁ, Martina MRAČKOVÁ, Ilona ELIÁŠOVÁ, Milena KOŠŤÁLOVÁ, Světlana SKUTILOVÁ and Irena REKTOROVÁ. Addenbrooke's Cognitive Examination and Individual Domain Cut-Off Scores for Discriminating between Different Cognitive Subtypes of Parkinson's Disease. Parkinson’s Disease. New York: Hindawi Publishing Corporation, 2015, vol. 2015, No 579417, p. 1-7. ISSN 2090-8083. Available from: https://dx.doi.org/10.1155/2015/579417.

Basic information

• Original name: Addenbrooke's Cognitive Examination and Individual Domain Cut-Off Scores for Discriminating between Different Cognitive Subtypes of Parkinson's Disease
• Authors: BERÁNKOVÁ, Dagmar (203 Czech Republic, belonging to the institution), Eva JANOUŠOVÁ (203 Czech Republic, belonging to the institution), Martina MRAČKOVÁ (203 Czech Republic, belonging to the institution), Ilona ELIÁŠOVÁ (203 Czech Republic, belonging to the institution), Milena KOŠŤÁLOVÁ (203 Czech Republic, belonging to the institution), Světlana SKUTILOVÁ (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Parkinson’s Disease, New York, Hindawi Publishing Corporation, 2015, 2090-8083.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 1.722
• RIV identification code: RIV/00216224:14110/15:00085053
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1155/2015/579417
• UT WoS: 000360499500001
• Keywords in English: REVISED ACE-R; DIAGNOSTIC-CRITERIA; IMPAIRMENT; DEMENTIA; VALIDATION; ACCURACY; UTILITY; COHORT
• Tags: EL OK, kontrola MP, MP, OA, rivok
• Tags: International impact, Reviewed

Abstract

Objective. The main aim of this study was to verify the sensitivity and specificity of Addenbrooke's Cognitive Examination-Revised (ACE-R) in discriminating between Parkinson's disease (PD) with normal cognition (PD-NC) and PD withmild cognitive impairment (PD-MCI) and between PD-MCI and PD with dementia (PD-D). We also evaluated how ACE-R correlates with neuropsychological cognitive tests in PD. Methods. We examined three age-matched groups of PD patients diagnosed according to the Movement Disorder Society Task Force criteria: PD-NC, PD-MCI, and PD-D. ROC analysis was used to establish specific cut-off scores of ACE-R and its domains. Correlation analyses were performed between ACE-R and its subtests with relevant neuropsychological tests. Results. Statistically significant differences between groups were demonstrated in global ACE-R scores and subscores, except in the language domain. ACE-R cut-off score of 88.5 points discriminated best between PD-MCI and PD-NC (sensitivity 0.68, specificity 0.91); ACE-R of 82.5 points distinguished best between PD-MCI and PD-D (sensitivity 0.70, specificity 0.73). The verbal fluency domain of ACE-R demonstrated the best discrimination between PD-NC and PD-MCI (cut-off score 11.5; sensitivity 0.70, specificity 0.73) while the orientation/attention subscore was best between PD-MCI and PD-D (cut-off score 15.5; sensitivity 0.90, specificity 0.97). ACE-R scores except for ACE-R language correlated with specific cognitive tests of interest.

Links

• ED1.1.00/02.0068, research and development project: Name: CEITEC - central european institute of technology
• NT13499, research and development project: Name: Řeč, její poruchy a kognitivní funkce u Parkinsonovy nemoci