BERÁNKOVÁ, Dagmar, Eva JANOUŠOVÁ, Martina MRAČKOVÁ, Ilona ELIÁŠOVÁ, Milena KOŠŤÁLOVÁ, Světlana SKUTILOVÁ and Irena REKTOROVÁ. Addenbrooke's Cognitive Examination and Individual Domain Cut-Off Scores for Discriminating between Different Cognitive Subtypes of Parkinson's Disease. Parkinson’s Disease. New York: Hindawi Publishing Corporation, 2015, vol. 2015, No 579417, p. 1-7. ISSN 2090-8083. doi:10.1155/2015/579417.
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Basic information
Original name Addenbrooke's Cognitive Examination and Individual Domain Cut-Off Scores for Discriminating between Different Cognitive Subtypes of Parkinson's Disease
Authors BERÁNKOVÁ, Dagmar (203 Czech Republic, belonging to the institution), Eva JANOUŠOVÁ (203 Czech Republic, belonging to the institution), Martina MRAČKOVÁ (203 Czech Republic, belonging to the institution), Ilona ELIÁŠOVÁ (203 Czech Republic, belonging to the institution), Milena KOŠŤÁLOVÁ (203 Czech Republic, belonging to the institution), Světlana SKUTILOVÁ (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, guarantor, belonging to the institution).
Edition Parkinson’s Disease, New York, Hindawi Publishing Corporation, 2015, 2090-8083.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 1.722
RIV identification code RIV/00216224:14110/15:00085053
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1155/2015/579417
UT WoS 000360499500001
Keywords in English REVISED ACE-R; DIAGNOSTIC-CRITERIA; IMPAIRMENT; DEMENTIA; VALIDATION; ACCURACY; UTILITY; COHORT
Tags EL OK, kontrola MP, MP, OA, rivok
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 15. 12. 2015 14:40.
Abstract
Objective. The main aim of this study was to verify the sensitivity and specificity of Addenbrooke's Cognitive Examination-Revised (ACE-R) in discriminating between Parkinson's disease (PD) with normal cognition (PD-NC) and PD withmild cognitive impairment (PD-MCI) and between PD-MCI and PD with dementia (PD-D). We also evaluated how ACE-R correlates with neuropsychological cognitive tests in PD. Methods. We examined three age-matched groups of PD patients diagnosed according to the Movement Disorder Society Task Force criteria: PD-NC, PD-MCI, and PD-D. ROC analysis was used to establish specific cut-off scores of ACE-R and its domains. Correlation analyses were performed between ACE-R and its subtests with relevant neuropsychological tests. Results. Statistically significant differences between groups were demonstrated in global ACE-R scores and subscores, except in the language domain. ACE-R cut-off score of 88.5 points discriminated best between PD-MCI and PD-NC (sensitivity 0.68, specificity 0.91); ACE-R of 82.5 points distinguished best between PD-MCI and PD-D (sensitivity 0.70, specificity 0.73). The verbal fluency domain of ACE-R demonstrated the best discrimination between PD-NC and PD-MCI (cut-off score 11.5; sensitivity 0.70, specificity 0.73) while the orientation/attention subscore was best between PD-MCI and PD-D (cut-off score 15.5; sensitivity 0.90, specificity 0.97). ACE-R scores except for ACE-R language correlated with specific cognitive tests of interest.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
NT13499, research and development projectName: Řeč, její poruchy a kognitivní funkce u Parkinsonovy nemoci
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