Addenbrooke's Cognitive Examination and Individual Domain
Cut-Off Scores for Discriminating between Different Cognitive
Subtypes of Parkinson's Disease

J 2015

Addenbrooke's Cognitive Examination and Individual Domain Cut-Off Scores for Discriminating between Different Cognitive Subtypes of Parkinson's Disease

BERÁNKOVÁ, Dagmar, Eva JANOUŠOVÁ, Martina MRAČKOVÁ, Ilona ELIÁŠOVÁ, Milena KOŠŤÁLOVÁ et. al.

Basic information

Original name

Addenbrooke's Cognitive Examination and Individual Domain Cut-Off Scores for Discriminating between Different Cognitive Subtypes of Parkinson's Disease

Authors

BERÁNKOVÁ, Dagmar (203 Czech Republic, belonging to the institution), Eva JANOUŠOVÁ (203 Czech Republic, belonging to the institution), Martina MRAČKOVÁ (203 Czech Republic, belonging to the institution), Ilona ELIÁŠOVÁ (203 Czech Republic, belonging to the institution), Milena KOŠŤÁLOVÁ (203 Czech Republic, belonging to the institution), Světlana SKUTILOVÁ (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Parkinson’s Disease, New York, Hindawi Publishing Corporation, 2015, 2090-8083

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.722

RIV identification code

RIV/00216224:14110/15:00085053

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1155/2015/579417

UT WoS

000360499500001

Keywords in English

REVISED ACE-R; DIAGNOSTIC-CRITERIA; IMPAIRMENT; DEMENTIA; VALIDATION; ACCURACY; UTILITY; COHORT

Abstract

V originále

Objective. The main aim of this study was to verify the sensitivity and specificity of Addenbrooke's Cognitive Examination-Revised (ACE-R) in discriminating between Parkinson's disease (PD) with normal cognition (PD-NC) and PD withmild cognitive impairment (PD-MCI) and between PD-MCI and PD with dementia (PD-D). We also evaluated how ACE-R correlates with neuropsychological cognitive tests in PD. Methods. We examined three age-matched groups of PD patients diagnosed according to the Movement Disorder Society Task Force criteria: PD-NC, PD-MCI, and PD-D. ROC analysis was used to establish specific cut-off scores of ACE-R and its domains. Correlation analyses were performed between ACE-R and its subtests with relevant neuropsychological tests. Results. Statistically significant differences between groups were demonstrated in global ACE-R scores and subscores, except in the language domain. ACE-R cut-off score of 88.5 points discriminated best between PD-MCI and PD-NC (sensitivity 0.68, specificity 0.91); ACE-R of 82.5 points distinguished best between PD-MCI and PD-D (sensitivity 0.70, specificity 0.73). The verbal fluency domain of ACE-R demonstrated the best discrimination between PD-NC and PD-MCI (cut-off score 11.5; sensitivity 0.70, specificity 0.73) while the orientation/attention subscore was best between PD-MCI and PD-D (cut-off score 15.5; sensitivity 0.90, specificity 0.97). ACE-R scores except for ACE-R language correlated with specific cognitive tests of interest.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

NT13499, research and development project

Name: Řeč, její poruchy a kognitivní funkce u Parkinsonovy nemoci

Files attached

1319699_Addenbrooke_s_Cognitive.pdf

Request the author's version of the file

ZVV_2015_145_1319699_Addenbrooke_s.pdf

Request the author's version of the file

Citovat

BERÁNKOVÁ, Dagmar, Eva JANOUŠOVÁ, Martina MRAČKOVÁ, Ilona ELIÁŠOVÁ, Milena KOŠŤÁLOVÁ, Světlana SKUTILOVÁ and Irena REKTOROVÁ. Addenbrooke's Cognitive Examination and Individual Domain Cut-Off Scores for Discriminating between Different Cognitive Subtypes of Parkinson's Disease. Parkinson’s Disease. New York: Hindawi Publishing Corporation, 2015, vol. 2015, No 579417, p. 1-7. ISSN 2090-8083. Available from: https://dx.doi.org/10.1155/2015/579417.

@article{1319699,
   author = {Beránková, Dagmar and Janoušová, Eva and Mračková, Martina and Eliášová, Ilona and Košťálová, Milena and Skutilová, Světlana and Rektorová, Irena},
   article_location = {New York},
   article_number = {579417},
   doi = {http://dx.doi.org/10.1155/2015/579417},
   keywords = {REVISED ACE-R; DIAGNOSTIC-CRITERIA; IMPAIRMENT; DEMENTIA; VALIDATION; ACCURACY; UTILITY; COHORT},
   language = {eng},
   issn = {2090-8083},
   journal = {Parkinson’s Disease},
   title = {Addenbrooke's Cognitive Examination and Individual Domain Cut-Off Scores for Discriminating between Different Cognitive Subtypes of Parkinson's Disease},
   url = {http://www.hindawi.com/journals/pd/2015/579417/},
   volume = {2015},
   year = {2015}
}

TY  - JOUR
ID  - 1319699
AU  - Beránková, Dagmar - Janoušová, Eva - Mračková, Martina - Eliášová, Ilona - Košťálová, Milena - Skutilová, Světlana - Rektorová, Irena
PY  - 2015
TI  - Addenbrooke's Cognitive Examination and Individual Domain Cut-Off Scores for Discriminating between Different Cognitive Subtypes of Parkinson's Disease
JF  - Parkinson’s Disease
VL  - 2015
IS  - 579417
SP  - 1-7
EP  - 1-7
PB  - Hindawi Publishing Corporation
SN  - 20908083
KW  - REVISED ACE-R
KW  - DIAGNOSTIC-CRITERIA
KW  - IMPAIRMENT
KW  - DEMENTIA
KW  - VALIDATION
KW  - ACCURACY
KW  - UTILITY
KW  - COHORT
UR  - http://www.hindawi.com/journals/pd/2015/579417/
N2  - Objective. The main aim of this study was to verify the sensitivity and specificity of Addenbrooke's Cognitive Examination-Revised (ACE-R) in discriminating between Parkinson's disease (PD) with normal cognition (PD-NC) and PD withmild cognitive impairment (PD-MCI) and between PD-MCI and PD with dementia (PD-D). We also evaluated how ACE-R correlates with neuropsychological cognitive tests in PD. Methods. We examined three age-matched groups of PD patients diagnosed according to the Movement Disorder Society Task Force criteria: PD-NC, PD-MCI, and PD-D. ROC analysis was used to establish specific cut-off scores of ACE-R and its domains. Correlation analyses were performed between ACE-R and its subtests with relevant neuropsychological tests. Results. Statistically significant differences between groups were demonstrated in global ACE-R scores and subscores, except in the language domain. ACE-R cut-off score of 88.5 points discriminated best between PD-MCI and PD-NC (sensitivity 0.68, specificity 0.91); ACE-R of 82.5 points distinguished best between PD-MCI and PD-D (sensitivity 0.70, specificity 0.73). The verbal fluency domain of ACE-R demonstrated the best discrimination between PD-NC and PD-MCI (cut-off score 11.5; sensitivity 0.70, specificity 0.73) while the orientation/attention subscore was best between PD-MCI and PD-D (cut-off score 15.5; sensitivity 0.90, specificity 0.97). ACE-R scores except for ACE-R language correlated with specific cognitive tests of interest.
ER  -

BERÁNKOVÁ, Dagmar, Eva JANOUŠOVÁ, Martina MRAČKOVÁ, Ilona ELIÁŠOVÁ, Milena KOŠŤÁLOVÁ, Světlana SKUTILOVÁ and Irena REKTOROVÁ. Addenbrooke's Cognitive Examination and Individual Domain Cut-Off Scores for Discriminating between Different Cognitive Subtypes of Parkinson's Disease. \textit{Parkinson’s Disease}. New York: Hindawi Publishing Corporation, 2015, vol.~2015, No~579417, p.~1-7. ISSN~2090-8083. Available from: https://dx.doi.org/10.1155/2015/579417.

Detailed Information on Publication Record