Linking Essential Tremor to the Cerebellum: Physiological
Evidence

J 2016

Linking Essential Tremor to the Cerebellum: Physiological Evidence

FILIP, Pavel, Ovidiu V. LUNGU, Mario-Ubaldo MANTO and Martin BAREŠ

Basic information

Original name

Linking Essential Tremor to the Cerebellum: Physiological Evidence

Authors

FILIP, Pavel (703 Slovakia, belonging to the institution), Ovidiu V. LUNGU (124 Canada), Mario-Ubaldo MANTO (56 Belgium) and Martin BAREŠ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Cerebellum, New York, Springer, 2016, 1473-4222

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.234

RIV identification code

RIV/00216224:14110/16:00089199

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s12311-015-0740-2

UT WoS

000387539000013

Keywords in English

Cerebellum; Essential tremor; Dynamic oscillatory network; Electrophysiology

Abstract

V originále

Essential tremor (ET), clinically characterized by postural and kinetic tremors, predominantly in the upper extremities, originates from pathological activity in the dynamic oscillatory network comprising the majority of nodes in the central motor network. Evidence indicates dysfunction in the thalamus, the olivocerebellar loops, and intermittent cortical engagement. Pathology of the cerebellum, a structure with architecture intrinsically predisposed to oscillatory activity, has also been implicated in ET as shown by clinical, neuroimaging, and pathological studies. Despite electrophysiological studies assessing cerebellar impairment in ET being scarce, their impact is tangible, as summarized in this review. The electromyography–magnetoencephalography combination provided the first direct evidence of pathological alteration in cortico-subcortical communication, with a significant emphasis on the cerebellum. Furthermore, complex electromyography studies showed disruptions in the timing of agonist and antagonist muscle activation, a process generally attributed to the cerebellum. Evidence pointing to cerebellar engagement in ET has also been found in electrooculography measurements, cerebellar repetitive transcranial magnetic stimulation studies, and, indirectly, in complex analyses of the activity of the ventral intermediate thalamic nucleus (an area primarily receiving inputs from the cerebellum), which is also used in the advanced treatment of ET. In summary, further progress in therapy will require comprehensive electrophysiological and physiological analyses to elucidate the precise mechanisms leading to disease symptoms. The cerebellum, as a major node of this dynamic oscillatory network, requires further study to aid this endeavor.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

Citovat

FILIP, Pavel, Ovidiu V. LUNGU, Mario-Ubaldo MANTO and Martin BAREŠ. Linking Essential Tremor to the Cerebellum: Physiological Evidence. Cerebellum. New York: Springer, 2016, vol. 15, No 6, p. 774-780. ISSN 1473-4222. Available from: https://dx.doi.org/10.1007/s12311-015-0740-2.

@article{1319837,
   author = {Filip, Pavel and Lungu, Ovidiu V. and Manto, MarioandUbaldo and Bareš, Martin},
   article_location = {New York},
   article_number = {6},
   doi = {http://dx.doi.org/10.1007/s12311-015-0740-2},
   keywords = {Cerebellum; Essential tremor; Dynamic oscillatory network; Electrophysiology},
   language = {eng},
   issn = {1473-4222},
   journal = {Cerebellum},
   title = {Linking Essential Tremor to the Cerebellum: Physiological Evidence},
   volume = {15},
   year = {2016}
}

TY  - JOUR
ID  - 1319837
AU  - Filip, Pavel - Lungu, Ovidiu V. - Manto, Mario-Ubaldo - Bareš, Martin
PY  - 2016
TI  - Linking Essential Tremor to the Cerebellum: Physiological Evidence
JF  - Cerebellum
VL  - 15
IS  - 6
SP  - 774-780
EP  - 774-780
PB  - Springer
SN  - 14734222
KW  - Cerebellum
KW  - Essential tremor
KW  - Dynamic oscillatory network
KW  - Electrophysiology
N2  - Essential tremor (ET), clinically characterized by postural and kinetic tremors, predominantly in the upper extremities, originates from pathological activity in the dynamic oscillatory network comprising the majority of nodes in the central motor network. Evidence indicates dysfunction in the thalamus, the olivocerebellar loops, and intermittent cortical engagement. Pathology of the cerebellum, a structure with architecture intrinsically predisposed to oscillatory activity, has also been implicated in ET as shown by clinical, neuroimaging, and pathological studies. Despite electrophysiological studies assessing cerebellar impairment in ET being scarce, their impact is tangible, as summarized in this review. The electromyography–magnetoencephalography combination provided the first direct evidence of pathological alteration in cortico-subcortical communication, with a significant emphasis on the cerebellum. Furthermore, complex electromyography studies showed disruptions in the timing of agonist and antagonist muscle activation, a process generally attributed to the cerebellum. Evidence pointing to cerebellar engagement in ET has also been found in electrooculography measurements, cerebellar repetitive transcranial magnetic stimulation studies, and, indirectly, in complex analyses of the activity of the ventral intermediate thalamic nucleus (an area primarily receiving inputs from the cerebellum), which is also used in the advanced treatment of ET. In summary, further progress in therapy will require comprehensive electrophysiological and physiological analyses to elucidate the precise mechanisms leading to disease symptoms. The cerebellum, as a major node of this dynamic oscillatory network, requires further study to aid this endeavor.
ER  -

FILIP, Pavel, Ovidiu V. LUNGU, Mario-Ubaldo MANTO and Martin BAREŠ. Linking Essential Tremor to the Cerebellum: Physiological Evidence. \textit{Cerebellum}. New York: Springer, 2016, vol.~15, No~6, p.~774-780. ISSN~1473-4222. Available from: https://dx.doi.org/10.1007/s12311-015-0740-2.

Detailed Information on Publication Record