Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma -
Czech Experience

a 2015

Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma - Czech Experience

KOLEK, Vitezslav, Libor HAVEL, Milos PESEK, Frantisek SALAJKA, Leona KOUBKOVA et. al.

Basic information

Original name

Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma - Czech Experience

Authors

KOLEK, Vitezslav (203 Czech Republic), Libor HAVEL (203 Czech Republic), Milos PESEK (203 Czech Republic), Frantisek SALAJKA (203 Czech Republic), Leona KOUBKOVA (203 Czech Republic), Jaromir ROUBEC (203 Czech Republic), Jana SKŘIČKOVÁ (203 Czech Republic, guarantor, belonging to the institution), Dimka SIXTOVA (203 Czech Republic), Karel HEJDUK (203 Czech Republic, belonging to the institution) and Zbyněk BORTLÍČEK (203 Czech Republic, belonging to the institution)

Edition

16th World Conference on Lung Cancer, 2015

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

30203 Respiratory systems

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 5.040

RIV identification code

RIV/00216224:14110/15:00085111

Organization unit

Faculty of Medicine

ISSN

Keywords in English

Mesothelioma; prognostic markers; survival

Abstract

V originále

Background: Malignant Pleural Mesotelioma (MPM) is a tumour with extremely unfavourable prognosis. Early diagnostic is rarely possible and chemotherapy has limited value in prolongation of survival. Pemetrexed with platinum is the standard 1st line chemotherapy. In the Czech Republic, the incidence of MPM is influenced mostly by former industry processing asbestos for roofs, other parts of buildings and isolation materials. Any work with asbetos is prohibited in the mean time. Methods: Treatment with pemetrexed and cisplatin was evaluated in a prospective study. Data of consecutive patients from 9 centers were prospectively collected from January 2008 till February 2015. Altogether 181 patients (47 women, 134 men) were evaluated. Mean age was 62 years, 71 pts were non smokers, 47 smokers, 61 ex smokers. Professional/ nonprofessional exposure was reported in 44/ 18 pts. Histology: 119 epithelial, 20 mixed, 12 sarcomatoid, not specified in 30 pts, TNM st.: I/II/III/IV in 19/32/48/78 pts, not assessed in 4 pts, PS: 0/1/2 in 39/130/12 pts. Results: Median of treatment was 18.5 weeks. Most frequent side effects (Gr 3, 4): leucopenia in 22, neutropenia in 15, anaemia in 15, trombocytopenia in 6, nausea/vomiting in 19, fatigue in 8 pts. Therapeutic response: CR in 5, PR in 47, SD 85, PD in 21 pts, overall disease control was 75.6 %. The median of overall survival (OS) was 19.8 months (16.2; 23.4), 1 year survival 67.9% (48.3; 71.5). Median of progression free survival (PFS) was 9.1 months (7.6; 10.7). Differences of survival were compared according to sex, smoking history, age, PS, TNM stage, treatment associated AE occurrence, type of exposure and histology. Significantly different results were achieved according to PS,TNM, exposure, AE and histology. Conclusion: Treatment of MPM with pemetrexed and cisplatinum in routine practice is effective and well tolerated. Prognosis is still poor and it is influenced by several clinical markers. Longer survival can be expected in PS 0, TNM I/II, unknown asbestos exposure, epitheloid histology and no treatment associated AE.

Citovat

KOLEK, Vitezslav, Libor HAVEL, Milos PESEK, Frantisek SALAJKA, Leona KOUBKOVA, Jaromir ROUBEC, Jana SKŘIČKOVÁ, Dimka SIXTOVA, Karel HEJDUK and Zbyněk BORTLÍČEK. Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma - Czech Experience. In 16th World Conference on Lung Cancer. 2015. ISSN 1556-0864.

@proceedings{1320378,
   author = {Kolek, Vitezslav and Havel, Libor and Pesek, Milos and Salajka, Frantisek and Koubkova, Leona and Roubec, Jaromir and Skřičková, Jana and Sixtova, Dimka and Hejduk, Karel and Bortlíček, Zbyněk},
   booktitle = {16th World Conference on Lung Cancer},
   keywords = {Mesothelioma; prognostic markers; survival},
   language = {eng},
   title = {Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma - Czech Experience},
   year = {2015}
}

TY  - CONF
ID  - 1320378
AU  - Kolek, Vitezslav - Havel, Libor - Pesek, Milos - Salajka, Frantisek - Koubkova, Leona - Roubec, Jaromir - Skřičková, Jana - Sixtova, Dimka - Hejduk, Karel - Bortlíček, Zbyněk
PY  - 2015
TI  - Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma - Czech Experience
KW  - Mesothelioma
KW  - prognostic markers
KW  - survival
N2  - Background: Malignant Pleural Mesotelioma (MPM) is a tumour with extremely unfavourable prognosis. Early diagnostic is rarely possible and chemotherapy has limited value in prolongation of survival. Pemetrexed with platinum is the standard 1st line chemotherapy. In the Czech Republic, the incidence of MPM is influenced mostly by former industry processing asbestos for roofs, other parts of buildings and isolation materials. Any work with asbetos is prohibited in the mean time. Methods: Treatment with pemetrexed and cisplatin was evaluated in a prospective study. Data of consecutive patients from 9 centers were prospectively collected from January 2008 till February 2015. Altogether 181 patients (47 women, 134 men) were evaluated. Mean age was 62 years, 71 pts were non smokers, 47 smokers, 61 ex smokers. Professional/ nonprofessional exposure was reported in 44/ 18 pts. Histology: 119 epithelial, 20 mixed, 12 sarcomatoid, not specified in 30 pts, TNM st.: I/II/III/IV in 19/32/48/78 pts, not assessed in 4 pts, PS: 0/1/2 in 39/130/12 pts. Results: Median of treatment was 18.5 weeks. Most frequent side effects (Gr 3, 4): leucopenia in 22, neutropenia in 15, anaemia in 15, trombocytopenia in 6, nausea/vomiting in 19, fatigue in 8 pts. Therapeutic response: CR in 5, PR in 47, SD 85, PD in 21 pts, overall disease control was 75.6 %. The median of overall survival (OS) was 19.8 months (16.2; 23.4), 1 year survival 67.9% (48.3; 71.5). Median of progression free survival (PFS) was 9.1 months (7.6; 10.7). Differences of survival were compared according to sex, smoking history, age, PS, TNM stage, treatment associated AE occurrence, type of exposure and histology. Significantly different results were achieved according to PS,TNM, exposure, AE and histology. Conclusion: Treatment of MPM with pemetrexed and cisplatinum in routine practice is effective and well tolerated. Prognosis is still poor and it is influenced by several clinical markers. Longer survival can be expected in PS 0, TNM I/II, unknown asbestos exposure, epitheloid histology and no treatment associated AE.
ER  -

KOLEK, Vitezslav, Libor HAVEL, Milos PESEK, Frantisek SALAJKA, Leona KOUBKOVA, Jaromir ROUBEC, Jana SKŘIČKOVÁ, Dimka SIXTOVA, Karel HEJDUK and Zbyněk BORTLÍČEK. Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma - Czech Experience. In \textit{16th World Conference on Lung Cancer}. 2015. ISSN~1556-0864.

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