| DUFEK, Michal, Irena REKTOROVÁ, Vojtěch THON, Jindřich LOKAJ and Ivan REKTOR. Interleukin-6 May Contribute to Mortality in Parkinson's Disease Patients: A 4-Year Prospective Study. Parkinsons Disease. New York: Hindawi Publishing Corporation, 2015, vol. 2015, No 898192, p. 1-5. ISSN 2090-8083. Available from: https://dx.doi.org/10.1155/2015/898192. |
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@article{1320444,
author = {Dufek, Michal and Rektorová, Irena and Thon, Vojtěch and Lokaj, Jindřich and Rektor, Ivan},
article_location = {New York},
article_number = {898192},
doi = {http://dx.doi.org/10.1155/2015/898192},
keywords = {GROWTH-FACTOR-ALPHA; C-REACTIVE PROTEIN; CEREBROSPINAL-FLUID; CYTOKINE PRODUCTION; ATHEROSCLEROSIS; INFLAMMATION; RISK; HEALTH; BRAIN; IL-6},
language = {eng},
issn = {2090-8083},
journal = {Parkinsons Disease},
title = {Interleukin-6 May Contribute to Mortality in Parkinson's Disease Patients: A 4-Year Prospective Study},
url = {http://www.hindawi.com/journals/pd/2015/898192/},
volume = {2015},
year = {2015}
}
TY - JOUR
ID - 1320444
AU - Dufek, Michal - Rektorová, Irena - Thon, Vojtěch - Lokaj, Jindřich - Rektor, Ivan
PY - 2015
TI - Interleukin-6 May Contribute to Mortality in Parkinson's Disease Patients: A 4-Year Prospective Study
JF - Parkinsons Disease
VL - 2015
IS - 898192
SP - 1-5
EP - 1-5
PB - Hindawi Publishing Corporation
SN - 20908083
KW - GROWTH-FACTOR-ALPHA
KW - C-REACTIVE PROTEIN
KW - CEREBROSPINAL-FLUID
KW - CYTOKINE PRODUCTION
KW - ATHEROSCLEROSIS
KW - INFLAMMATION
KW - RISK
KW - HEALTH
KW - BRAIN
KW - IL-6
UR - http://www.hindawi.com/journals/pd/2015/898192/
N2 - Objectives. The association between abnormal serum immunomarkers and mortality in 53 consecutive Parkinson's disease patients was studied. Materials and Methods. The plasma level of specific inflammatory cytokines was investigated: mannan-binding lectin (MBL), interleukin-(IL-) 6, and tumor necrosis factor-alpha (TNF-alpha). The baseline serum immunomarkers obtained from patients who died (n = 16) during a four-year follow-up period were compared with the data of patients who survived (n = 37). Results. The baseline level of IL-6 was significantly higher in the deceased patients than in the survivors. Elevated IL-6 levels and age were major independent contributors to disease mortality. Differences between other plasma cytokine level abnormalities were not significant. Conclusion. This study showed that IL-6 elevation may be a marker of increased mortality risk in Parkinson's disease patients. The inflammation may act in association with other factors and comorbidities in progressive neurodegenerative pathology.
ER -
DUFEK, Michal, Irena REKTOROVÁ, Vojtěch THON, Jindřich LOKAJ and Ivan REKTOR. Interleukin-6 May Contribute to Mortality in Parkinson's Disease Patients: A 4-Year Prospective Study. \textit{Parkinsons Disease}. New York: Hindawi Publishing Corporation, 2015, vol.~2015, No~898192, p.~1-5. ISSN~2090-8083. Available from: https://dx.doi.org/10.1155/2015/898192.
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