Interleukin-6 May Contribute to Mortality in Parkinson's
Disease Patients: A 4-Year Prospective Study

J 2015

Interleukin-6 May Contribute to Mortality in Parkinson's Disease Patients: A 4-Year Prospective Study

DUFEK, Michal, Irena REKTOROVÁ, Vojtěch THON, Jindřich LOKAJ, Ivan REKTOR et. al.

Basic information

Original name

Interleukin-6 May Contribute to Mortality in Parkinson's Disease Patients: A 4-Year Prospective Study

Authors

DUFEK, Michal (203 Czech Republic, guarantor), Irena REKTOROVÁ (203 Czech Republic, belonging to the institution), Vojtěch THON (203 Czech Republic, belonging to the institution), Jindřich LOKAJ (203 Czech Republic, belonging to the institution) and Ivan REKTOR (203 Czech Republic, belonging to the institution)

Edition

Parkinsons Disease, New York, Hindawi Publishing Corporation, 2015, 2090-8083

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.722

RIV identification code

RIV/00216224:14110/15:00085127

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1155/2015/898192

UT WoS

000360499700001

Keywords in English

GROWTH-FACTOR-ALPHA; C-REACTIVE PROTEIN; CEREBROSPINAL-FLUID; CYTOKINE PRODUCTION; ATHEROSCLEROSIS; INFLAMMATION; RISK; HEALTH; BRAIN; IL-6

Abstract

V originále

Objectives. The association between abnormal serum immunomarkers and mortality in 53 consecutive Parkinson's disease patients was studied. Materials and Methods. The plasma level of specific inflammatory cytokines was investigated: mannan-binding lectin (MBL), interleukin-(IL-) 6, and tumor necrosis factor-alpha (TNF-alpha). The baseline serum immunomarkers obtained from patients who died (n = 16) during a four-year follow-up period were compared with the data of patients who survived (n = 37). Results. The baseline level of IL-6 was significantly higher in the deceased patients than in the survivors. Elevated IL-6 levels and age were major independent contributors to disease mortality. Differences between other plasma cytokine level abnormalities were not significant. Conclusion. This study showed that IL-6 elevation may be a marker of increased mortality risk in Parkinson's disease patients. The inflammation may act in association with other factors and comorbidities in progressive neurodegenerative pathology.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

Files attached

EL_1320444.pdf

Request the author's version of the file

Citovat

DUFEK, Michal, Irena REKTOROVÁ, Vojtěch THON, Jindřich LOKAJ and Ivan REKTOR. Interleukin-6 May Contribute to Mortality in Parkinson's Disease Patients: A 4-Year Prospective Study. Parkinsons Disease. New York: Hindawi Publishing Corporation, 2015, vol. 2015, No 898192, p. 1-5. ISSN 2090-8083. Available from: https://dx.doi.org/10.1155/2015/898192.

@article{1320444,
   author = {Dufek, Michal and Rektorová, Irena and Thon, Vojtěch and Lokaj, Jindřich and Rektor, Ivan},
   article_location = {New York},
   article_number = {898192},
   doi = {http://dx.doi.org/10.1155/2015/898192},
   keywords = {GROWTH-FACTOR-ALPHA; C-REACTIVE PROTEIN; CEREBROSPINAL-FLUID; CYTOKINE PRODUCTION; ATHEROSCLEROSIS; INFLAMMATION; RISK; HEALTH; BRAIN; IL-6},
   language = {eng},
   issn = {2090-8083},
   journal = {Parkinsons Disease},
   title = {Interleukin-6 May Contribute to Mortality in Parkinson's Disease Patients: A 4-Year Prospective Study},
   url = {http://www.hindawi.com/journals/pd/2015/898192/},
   volume = {2015},
   year = {2015}
}

TY  - JOUR
ID  - 1320444
AU  - Dufek, Michal - Rektorová, Irena - Thon, Vojtěch - Lokaj, Jindřich - Rektor, Ivan
PY  - 2015
TI  - Interleukin-6 May Contribute to Mortality in Parkinson's Disease Patients: A 4-Year Prospective Study
JF  - Parkinsons Disease
VL  - 2015
IS  - 898192
SP  - 1-5
EP  - 1-5
PB  - Hindawi Publishing Corporation
SN  - 20908083
KW  - GROWTH-FACTOR-ALPHA
KW  - C-REACTIVE PROTEIN
KW  - CEREBROSPINAL-FLUID
KW  - CYTOKINE PRODUCTION
KW  - ATHEROSCLEROSIS
KW  - INFLAMMATION
KW  - RISK
KW  - HEALTH
KW  - BRAIN
KW  - IL-6
UR  - http://www.hindawi.com/journals/pd/2015/898192/
N2  - Objectives. The association between abnormal serum immunomarkers and mortality in 53 consecutive Parkinson's disease patients was studied. Materials and Methods. The plasma level of specific inflammatory cytokines was investigated: mannan-binding lectin (MBL), interleukin-(IL-) 6, and tumor necrosis factor-alpha (TNF-alpha). The baseline serum immunomarkers obtained from patients who died (n = 16) during a four-year follow-up period were compared with the data of patients who survived (n = 37). Results. The baseline level of IL-6 was significantly higher in the deceased patients than in the survivors. Elevated IL-6 levels and age were major independent contributors to disease mortality. Differences between other plasma cytokine level abnormalities were not significant. Conclusion. This study showed that IL-6 elevation may be a marker of increased mortality risk in Parkinson's disease patients. The inflammation may act in association with other factors and comorbidities in progressive neurodegenerative pathology.
ER  -

DUFEK, Michal, Irena REKTOROVÁ, Vojtěch THON, Jindřich LOKAJ and Ivan REKTOR. Interleukin-6 May Contribute to Mortality in Parkinson's Disease Patients: A 4-Year Prospective Study. \textit{Parkinsons Disease}. New York: Hindawi Publishing Corporation, 2015, vol.~2015, No~898192, p.~1-5. ISSN~2090-8083. Available from: https://dx.doi.org/10.1155/2015/898192.

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