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@article{1320648,
author = {Dobšák, Petr and Soška, Vladimír and Sochor, Ondřej and Jarkovský, Jiří and Nováková, Marie and Homolka, Martin and Souček, Miroslav and Palanová, Petra and LopezandJimenez, Francisco and Shirai, Kohji},
article_location = {Tokyo},
article_number = {3},
keywords = {Cardio-ankle vascular index; Combined hyperlipidemia; Hypercholesterolemia},
language = {eng},
issn = {1340-3478},
journal = {Journal of Atherosclerosis and Thrombosis},
title = {Increased Cardio-ankle Vascular Index in Hyperlipidemic Patients without Diabetes or Hypertension},
volume = {22},
year = {2015}
}
TY - JOUR
ID - 1320648
AU - Dobšák, Petr - Soška, Vladimír - Sochor, Ondřej - Jarkovský, Jiří - Nováková, Marie - Homolka, Martin - Souček, Miroslav - Palanová, Petra - Lopez-Jimenez, Francisco - Shirai, Kohji
PY - 2015
TI - Increased Cardio-ankle Vascular Index in Hyperlipidemic Patients without Diabetes or Hypertension
JF - Journal of Atherosclerosis and Thrombosis
VL - 22
IS - 3
SP - 272-283
EP - 272-283
PB - Japan Atherosclerosis Society
SN - 13403478
KW - Cardio-ankle vascular index
KW - Combined hyperlipidemia
KW - Hypercholesterolemia
N2 - Aim: The cardio-ankle vascular index (CAVI) is a sensitive non-invasive marker of arterial stiffness and atherosclerosis. The aim of this work was to compare the CAVI values in patients with dyslipidemia (without diabetes mellitus and hypertension) and healthy controls. Methods: A Total 248 subjects with dyslipidemia (104 men, 144 women), 55.0 (95% CI 30-70) years of age with combined hyperlipidemia or primary hypercholesterolemia and 537 healthy controls (244 men, 293 women) 40.0 (95% CI 26-62) years of age were included in this study. Fasting blood samples were collected to measure the serum total cholesterol, triglyceride, HDL-cholesterol and apolipoprotein A1 and B levels. The LDL cholesterol level was also calculated, and the CAVI was measured using the VaSera (R) 1500 system. Results: The CAVI values were significantly higher in the dyslipidemic patients (8.08, 95% CI 6.00-10.05) than in the controls (7.11, 95% CI 5.77-9.05; p<0.01). In addition, the CAVI values were elevated in both subgroups of patients with hypercholesterolemia (7.95, 95% CI 5.85-6.90; p<0.01) and combined hyperlipidemia (8.30, 95% CI 6.60-10.15; p<0.01) in comparison with those observed in the controls. After adopting the propensity score method in order to balance the confounding factors (age, gender, body mass index) and adjust the analysis for diastolic blood pressure, the CAVI values in the dyslipidemic patients remained significantly high (7.78, 95% CI 5.80-9.69) compared to that observed in the controls (7.31, 95% CI 5.44-9.35; p<0.001). However, the CAVI values did not differ significantly between the controls and both subgroups of dyslipidemic patients (primary hypercholesterolemia, combined hyperlipidemia). Conclusions: The present findings demonstrated that dyslipidemia increases the CAVI values in comparison to that seen in healthy subjects.
ER -
DOBŠÁK, Petr, Vladimír SOŠKA, Ondřej SOCHOR, Jiří JARKOVSKÝ, Marie NOVÁKOVÁ, Martin HOMOLKA, Miroslav SOUČEK, Petra PALANOVÁ, Francisco LOPEZ-JIMENEZ and Kohji SHIRAI. Increased Cardio-ankle Vascular Index in Hyperlipidemic Patients without Diabetes or Hypertension. \textit{Journal of Atherosclerosis and Thrombosis}. Tokyo: Japan Atherosclerosis Society, 2015, vol.~22, No~3, p.~272-283. ISSN~1340-3478.
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