Using ASL Method for Monitoring of Brain Perfusion Changes in a
Rat Model of Schizophrenia and After Chronic Administration of
Aripiprazole.

D 2015

Using ASL Method for Monitoring of Brain Perfusion Changes in a Rat Model of Schizophrenia and After Chronic Administration of Aripiprazole.

DRAŽANOVÁ, Eva, Lucie GROSSOVÁ, Jana PISTOVČÁKOVÁ, Amit Suresh KHAIRNAR, Regina DEMLOVÁ et. al.

Basic information

Original name

Using ASL Method for Monitoring of Brain Perfusion Changes in a Rat Model of Schizophrenia and After Chronic Administration of Aripiprazole.

Authors

DRAŽANOVÁ, Eva (203 Czech Republic, guarantor, belonging to the institution), Lucie GROSSOVÁ (203 Czech Republic), Jana PISTOVČÁKOVÁ (203 Czech Republic, belonging to the institution), Amit Suresh KHAIRNAR (203 Czech Republic, belonging to the institution), Regina DEMLOVÁ (203 Czech Republic, belonging to the institution), Tomáš KAŠPÁREK (203 Czech Republic, belonging to the institution) and Zenon STARČUK (203 Czech Republic, belonging to the institution)

Edition

Bratislava, Measurement 2015 : Proceedings of the 10th International Conference on Measurement, p. 81-84, 4 pp. 2015

Publisher

Institute of Measurement Science, SAS

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Slovakia

Confidentiality degree

není předmětem státního či obchodního tajemství

Publication form

printed version "print"

References:

URL

RIV identification code

RIV/00216224:14110/15:00095810

Organization unit

Faculty of Medicine

ISBN

978-80-969672-9-2

Keywords in English

ASL; schizophrenia; poly I:C animal model; rats; aripiprazole

Abstract

V originále

Animals prenatally exposed to polyriboinosinic–polyribocytidilic acid (poly I:C) can be used to parallel neuropathological abnormalities seen in schizophrenia patients. The aim of this study was to test the utility of Arterial Spin Labeling (ASL) MRI method for the evaluation of perfusion in different brain regions in the developmental poly I:C model of schizophrenia in rats. In these animals we further investigated the effect of chronic administration of the antipsychotic aripiprazole on brain perfusion. In the circle of Willis region, we observed significant increase of blood perfusion in the poly I:C model of schizophrenia in both males and females, and significantly higher perfusion in males than in females in vehicle-treated controls. Perfusion in hippocampus (in both hemispheres) was found significantly higher in males than in females in both vehicle-treated controls and poly I:C prenatally exposed animals. The significantly increased blood perfusion in the circle of Willis in poly I:C prenatally exposed males was found to persist even after chronic administration of aripiprazole. These results add new data to understanding of antipsychotic effects and demonstrate the viability of the proposed approach of combination of the ASL MRI method and the selected rat model of schizophrenia.

Links

LM2011017, research and development project

Name: Advanced Cell Immunotherapy Unit - ACIU

Investor: Ministry of Education, Youth and Sports of the CR

MUNI/A/1116/2014, interní kód MU

Name: Nové farmakologické mechanizmy v preklinickém i klinickém vývoji léčiv

Investor: Masaryk University, Category A

Citovat

DRAŽANOVÁ, Eva, Lucie GROSSOVÁ, Jana PISTOVČÁKOVÁ, Amit Suresh KHAIRNAR, Regina DEMLOVÁ, Tomáš KAŠPÁREK and Zenon STARČUK. Using ASL Method for Monitoring of Brain Perfusion Changes in a Rat Model of Schizophrenia and After Chronic Administration of Aripiprazole. In Ján Maňka, Milan Tyšler, Vikor Witkovský, Ivan Frollo. Measurement 2015 : Proceedings of the 10th International Conference on Measurement. Bratislava: Institute of Measurement Science, SAS, 2015, p. 81-84. ISBN 978-80-969672-9-2.

@inproceedings{1321601,
   author = {Dražanová, Eva and Grossová, Lucie and Pistovčáková, Jana and Khairnar, Amit Suresh and Demlová, Regina and Kašpárek, Tomáš and Starčuk, Zenon},
   address = {Bratislava},
   booktitle = {Measurement 2015 : Proceedings of the 10th International Conference on Measurement},
   editor = {Ján Maňka, Milan Tyšler, Vikor Witkovský, Ivan Frollo},
   keywords = {ASL; schizophrenia; poly I:C animal model; rats; aripiprazole},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {Bratislava},
   isbn = {978-80-969672-9-2},
   pages = {81-84},
   publisher = {Institute of Measurement Science, SAS},
   title = {Using ASL Method for Monitoring of Brain Perfusion Changes in a Rat Model of Schizophrenia and After Chronic Administration of Aripiprazole.},
   url = {http://hdl.handle.net/11104/0248090},
   year = {2015}
}

TY  - JOUR
ID  - 1321601
AU  - Dražanová, Eva - Grossová, Lucie - Pistovčáková, Jana - Khairnar, Amit Suresh - Demlová, Regina - Kašpárek, Tomáš - Starčuk, Zenon
PY  - 2015
TI  - Using ASL Method for Monitoring of Brain Perfusion Changes in a Rat Model of Schizophrenia and After Chronic Administration of Aripiprazole.
PB  - Institute of Measurement Science, SAS
CY  - Bratislava
SN  - 9788096967292
KW  - ASL
KW  - schizophrenia
KW  - poly I:C animal model
KW  - rats
KW  - aripiprazole
UR  - http://hdl.handle.net/11104/0248090
N2  - Animals prenatally exposed to polyriboinosinic–polyribocytidilic acid (poly I:C) can be used to parallel neuropathological abnormalities seen in schizophrenia patients. The aim of this study was to test the utility of Arterial Spin Labeling (ASL) MRI method for the evaluation of perfusion in different brain regions in the developmental poly I:C model of schizophrenia in rats. In these animals we further investigated the effect of chronic administration of the antipsychotic aripiprazole on brain perfusion. In the circle of Willis region, we observed significant increase of blood perfusion in the poly I:C model of schizophrenia in both males and females, and significantly higher perfusion in males than in females in vehicle-treated controls. Perfusion in hippocampus (in both hemispheres) was found significantly higher in males than in females in both vehicle-treated controls and poly I:C prenatally exposed animals. The significantly increased blood perfusion in the circle of Willis in poly I:C prenatally exposed males was found to persist even after chronic administration of aripiprazole. These results add new data to understanding of antipsychotic effects and demonstrate the viability of the proposed approach of combination of the ASL MRI method and the selected rat model of schizophrenia.
ER  -

DRAŽANOVÁ, Eva, Lucie GROSSOVÁ, Jana PISTOVČÁKOVÁ, Amit Suresh KHAIRNAR, Regina DEMLOVÁ, Tomáš KAŠPÁREK and Zenon STARČUK. Using ASL Method for Monitoring of Brain Perfusion Changes in a Rat Model of Schizophrenia and After Chronic Administration of Aripiprazole. In Ján Maňka, Milan Tyšler, Vikor Witkovský, Ivan Frollo. \textit{Measurement 2015 : Proceedings of the 10th International Conference on Measurement}. Bratislava: Institute of Measurement Science, SAS, 2015, p.~81-84. ISBN~978-80-969672-9-2.

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