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@article{1321694,
author = {Veselka, Josef and Zemánek, David and Jahnlová, Denisa and Krejčí, Jan and Januška, Jaroslav and Dabrowski, Maciej and Bartel, Thomas and Tomašov, Pavol},
article_location = {New York},
article_number = {10},
doi = {http://dx.doi.org/10.1016/j.cjca.2015.02.010},
keywords = {SUDDEN CARDIAC DEATH; LONG-TERM SURVIVAL; TASK-FORCE; MULTICENTER; PREVENTION; GUIDELINES; EXPERIENCE; DIAGNOSIS; MYECTOMY; THERAPY},
language = {eng},
issn = {0828-282X},
journal = {Canadian Journal of Cardiology},
title = {Risk and Causes of Death in Patients After Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy},
volume = {31},
year = {2015}
}
TY - JOUR
ID - 1321694
AU - Veselka, Josef - Zemánek, David - Jahnlová, Denisa - Krejčí, Jan - Januška, Jaroslav - Dabrowski, Maciej - Bartel, Thomas - Tomašov, Pavol
PY - 2015
TI - Risk and Causes of Death in Patients After Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy
JF - Canadian Journal of Cardiology
VL - 31
IS - 10
SP - 1245-1251
EP - 1245-1251
PB - Elsevier Science Ltd.
SN - 0828282X
KW - SUDDEN CARDIAC DEATH
KW - LONG-TERM SURVIVAL
KW - TASK-FORCE
KW - MULTICENTER
KW - PREVENTION
KW - GUIDELINES
KW - EXPERIENCE
KW - DIAGNOSIS
KW - MYECTOMY
KW - THERAPY
N2 - Background: Because the final myocardial scar might be theoretically associated with an increased risk of sudden cardiac death, the longterm clinical course of patients who undergo alcohol septal ablation (ASA) is still a matter of debate. In this retrospective multicentre study, we report outcomes after ASA, including survival, analysis of causes of deaths, and association between time and cause of death. Methods: We enrolled 366 consecutive patients (58 +/- 12 years, 54% women) who were treated using ASA and followed-up for 5.1 +/- 4.5 years. Results: The in-hospital and 30-day mortality were 0.5% and 0.8%, respectively; the ASA-related morbidity was < 20%. Overall, 52 patients died during 1867 patient-years, which means the all-cause mortality rate was 2.8% per year. The mortality rates of sudden death and sudden death with an appropriate implantable cardioverterdefibrillator (ICD) discharge were 0.4% and 1% per year, respectively. Patients with sudden death or appropriate ICD discharge experienced these mortality events at younger age than patients who died of other hypertrophic obstructive cardiomyopathy-related causes (60.8 years [range, 52-71.5 years] vs 72.4 years [range, 64.2-75.2 years]; P = 0.048). A total of 292 patients (80%) had an outflow gradient <= 30 mm Hg, and 327 patients (89%) were in New York Heart Association class <= II at the last clinical check-up. Conclusions: ASA had low procedure-related mortality, with subsequent 1% occurrence of sudden mortality events per year and 2.8% mortality rate per year in the long-term follow-up. Patients with sudden death or ICD discharge experienced the mortality events approximately 1 decade earlier than patients who died from other causes not related to hypertrophic cardiomyopathy.
ER -
VESELKA, Josef, David ZEMÁNEK, Denisa JAHNLOVÁ, Jan KREJČÍ, Jaroslav JANUŠKA, Maciej DABROWSKI, Thomas BARTEL a Pavol TOMAŠOV. Risk and Causes of Death in Patients After Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy. \textit{Canadian Journal of Cardiology}. New York: Elsevier Science Ltd., roč.~31, č.~10, s.~1245-1251. ISSN~0828-282X. doi:10.1016/j.cjca.2015.02.010. 2015.
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