| ELFMARKOVÁ, Nela, Martin GAJDOŠ, Martina MRAČKOVÁ, Jiří MEKYSKA, Michal MIKL and Irena REKTOROVÁ. Impact of Parkinson's disease and levodopa on resting state functional connectivity related to speech prosody control. PARKINSONISM & RELATED DISORDERS. OXFORD: ELSEVIER SCI LTD, 2016, vol. 22, Supplement 1, p. "S52"-"S55", 4 pp. ISSN 1353-8020. Available from: https://dx.doi.org/10.1016/j.parkreldis.2015.09.006. |
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@article{1321778,
author = {Elfmarková, Nela and Gajdoš, Martin and Mračková, Martina and Mekyska, Jiří and Mikl, Michal and Rektorová, Irena},
article_location = {OXFORD},
article_number = {Supplement 1},
doi = {http://dx.doi.org/10.1016/j.parkreldis.2015.09.006},
keywords = {Parkinson's disease; Functional connectivity; Speech prosody; fMRI; Resting state; Dopaminergic; Levodopa; Acoustic; Motor speech network; Caudate nucleus},
language = {eng},
issn = {1353-8020},
journal = {PARKINSONISM & RELATED DISORDERS},
title = {Impact of Parkinson's disease and levodopa on resting state functional connectivity related to speech prosody control},
url = {http://www.sciencedirect.com/science/article/pii/S1353802015003818},
volume = {22},
year = {2016}
}
TY - JOUR
ID - 1321778
AU - Elfmarková, Nela - Gajdoš, Martin - Mračková, Martina - Mekyska, Jiří - Mikl, Michal - Rektorová, Irena
PY - 2016
TI - Impact of Parkinson's disease and levodopa on resting state functional connectivity related to speech prosody control
JF - PARKINSONISM & RELATED DISORDERS
VL - 22
IS - Supplement 1
SP - "S52"-"S55"
EP - "S52"-"S55"
PB - ELSEVIER SCI LTD
SN - 13538020
KW - Parkinson's disease
KW - Functional connectivity
KW - Speech prosody
KW - fMRI
KW - Resting state
KW - Dopaminergic
KW - Levodopa
KW - Acoustic
KW - Motor speech network
KW - Caudate nucleus
UR - http://www.sciencedirect.com/science/article/pii/S1353802015003818
L2 - http://www.sciencedirect.com/science/article/pii/S1353802015003818
N2 - Background: Impaired speech prosody is common in Parkinson's disease (PD). We assessed the impact of PD and levodopa on MRI resting-state functional connectivity (rs-FC) underlying speech prosody control. Methods: We studied 19 PD patients in the OFF and ON dopaminergic conditions and 15 age-matched healthy controls using functional MRI and seed partial least squares correlation (PLSC) analysis. In the PD group, we also correlated levodopa-induced rs-FC changes with the results of acoustic analysis. Results: The PLCS analysis revealed a significant impact of PD but not of medication on the rs-FC strength of spatial correlation maps seeded by the anterior cingulate (p = 0.006), the right orofacial primary sensorimotor cortex (OF_SM1; p = 0.025) and the right caudate head (CN; p = 0.047). In the PD group, levodopa-induced changes in the CN and OF_SM1 connectivity strengths were related to changes in speech prosody. Conclusions: We demonstrated an impact of PD but not of levodopa on rs-FC within the brain networks related to speech prosody control. When only the PD patients were taken into account, the association between treatment-induced changes in speech prosody and changes in rs-FC within the associative striato-prefrontal and motor speech networks was found. (C) 2015 Elsevier Ltd. All rights reserved.
ER -
ELFMARKOVÁ, Nela, Martin GAJDOŠ, Martina MRAČKOVÁ, Jiří MEKYSKA, Michal MIKL and Irena REKTOROVÁ. Impact of Parkinson's disease and levodopa on resting state functional connectivity related to speech prosody control. \textit{PARKINSONISM \&{} RELATED DISORDERS}. OXFORD: ELSEVIER SCI LTD, 2016, vol.~22, Supplement 1, p.~''S52''-''S55'', 4 pp. ISSN~1353-8020. Available from: https://dx.doi.org/10.1016/j.parkreldis.2015.09.006.
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