The clinical phenomenology and associations of trick maneuvers in cervical dystonia

FILIP, Pavel, Marek BALÁŽ, Rastislav ŠUMEC and Martin BAREŠ. The clinical phenomenology and associations of trick maneuvers in cervical dystonia. Journal of Neural Transmission. Wien: Springer Wien, 2016, vol. 123, No 3, p. 269-275. ISSN 0300-9564. Available from: https://dx.doi.org/10.1007/s00702-015-1488-z.

Basic information

• Original name: The clinical phenomenology and associations of trick maneuvers in cervical dystonia
• Authors: FILIP, Pavel (703 Slovakia, belonging to the institution), Marek BALÁŽ (703 Slovakia, belonging to the institution), Rastislav ŠUMEC (703 Slovakia, belonging to the institution) and Martin BAREŠ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Journal of Neural Transmission, Wien, Springer Wien, 2016, 0300-9564.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: Austria
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 2.392
• RIV identification code: RIV/00216224:14110/16:00088837
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1007/s00702-015-1488-z
• UT WoS: 000373162900014
• Keywords in English: Sensory trick; Cervical dystonia; Botulinum toxin; Treatment effectiveness
• Tags: EL OK, podil
• Tags: International impact, Reviewed

Abstract

Sensory trick is an unusual clinical feature in cervical dystonia that attenuates disease symptoms by slight touch to a specific area of the face or head. Using a semi-quantitative questionnaire-based study of 197 patients with idiopathic cervical dystonia, we sought to determine probable pathophysiologic correlates, with the wider aim of examining its eventual clinical significance. The typical sensory trick, i.e., light touch, not necessitating the use of force leading to simple overpowering of dystonic activity, was present in 83 (42.1 %) patients. The vast majority of the patients required a specific sequence of sensorimotor inputs, including touch sensation on the face or different areas of the head, and also sensory and motor input of the hand itself. Deviations often led to a significant decrease in effectiveness and lack of expected benefit. Moreover, patients able to perform the maneuver reported compellingly higher subjective effect of botulinum toxin treatment (median 7 vs. 5 on a scale of 0–10; p\0.0001) and lower depression score (median 10 vs. 14 on the Montgomery Asberg Depression Rating scale; p\0.001). Overall, the results point to marked disruption of sensorimotor networks in cervical dystonia. The mechanism of the sensory trick action may be associated with balancing the abnormal activation patterns by specific sensorimotor inputs. Its presence may be considered a positive predictive factor for responsiveness to botulinum toxin treatment.

Links

• ED1.1.00/02.0068, research and development project: Name: CEITEC - central european institute of technology
• NT13437, research and development project: Name: Mozeček, kognitivní dysfunkce a mechanismy kontroly pohybu a odhadu času u dystonie a schizofrenie.