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@article{1322637, author = {Paleček, Jan and Gruber, Stephan}, article_location = {CAMBRIDGE}, article_number = {12}, doi = {http://dx.doi.org/10.1016/j.str.2015.10.004}, keywords = {SMC structural maintenance of chromosomes; Cohesin; Condensin; Smc5/6; MukBEF; MksBEF; MAGE; Smc/ScpAB; kleisin; chromosome segregation; cohesion; condensation; replication; winged helix domains; kite proteins}, language = {eng}, issn = {0969-2126}, journal = {Structure}, title = {Kite Proteins: a Superfamily of SMC/Kleisin Partners Conserved Across Bacteria, Archaea, and Eukaryotes}, url = {http://www.sciencedirect.com/science/article/pii/S0969212615004128}, volume = {23}, year = {2015} }
TY - JOUR ID - 1322637 AU - Paleček, Jan - Gruber, Stephan PY - 2015 TI - Kite Proteins: a Superfamily of SMC/Kleisin Partners Conserved Across Bacteria, Archaea, and Eukaryotes JF - Structure VL - 23 IS - 12 SP - 2183-2190 EP - 2183-2190 PB - CELL PRESS SN - 09692126 KW - SMC structural maintenance of chromosomes KW - Cohesin KW - Condensin KW - Smc5/6 KW - MukBEF KW - MksBEF KW - MAGE KW - Smc/ScpAB KW - kleisin KW - chromosome segregation KW - cohesion KW - condensation KW - replication KW - winged helix domains KW - kite proteins UR - http://www.sciencedirect.com/science/article/pii/S0969212615004128 L2 - http://www.sciencedirect.com/science/article/pii/S0969212615004128 N2 - SMC/kleisin complexes form elongated annular structures, which are critical for chromosome segregation, genome maintenance, and the regulation of gene expression. We describe marked structural similarities between bacterial and eukaryotic SMC/kleisin partner proteins (designated here as "kite'' proteins for kleisin interacting tandem winged-helix (WH) elements of SMC complexes). Kite proteins are integral parts of all prokaryotic SMC complexes and Smc5/6 but not cohesin and condensin. They are made up of tandem WH domains, form homo-or heterodimers via their amino-terminal WH domain, and they associate with the central part of a kleisin subunit. In placental mammals, the kite subunit NSE3 gave rise to several (>60) kite-related proteins, named MAGE, many of which encode tumor-and testis-specific antigens. Based on architectural rather than sequence similarity, we propose an adapted model for the evolution of the SMC protein complexes and discuss potential functional similarities between bacterial Smc/ScpAB and eukaryotic Smc5/6. ER -
PALEČEK, Jan and Stephan GRUBER. Kite Proteins: a Superfamily of SMC/Kleisin Partners Conserved Across Bacteria, Archaea, and Eukaryotes. \textit{Structure}. CAMBRIDGE: CELL PRESS, 2015, vol.~23, No~12, p.~2183-2190. ISSN~0969-2126. Available from: https://dx.doi.org/10.1016/j.str.2015.10.004.
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