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@article{1322754,
author = {Červeň, Jiří and Havran, Luděk and Pečinka, Petr and Fojta, Miroslav},
article_location = {WEINHEIM},
article_number = {10},
doi = {http://dx.doi.org/10.1002/elan.201500177},
keywords = {Wedelolactone; Electrochemistry; Graphite electrode; DNA; Doxorubicin},
language = {eng},
issn = {1040-0397},
journal = {Electroanalysis},
title = {Electrochemical Activity of Wedelolactone and Probing its Interaction with DNA Using Voltammetry at a Carbon Electrode},
url = {http://onlinelibrary.wiley.com/doi/10.1002/elan.201500177/epdf},
volume = {27},
year = {2015}
}
TY - JOUR
ID - 1322754
AU - Červeň, Jiří - Havran, Luděk - Pečinka, Petr - Fojta, Miroslav
PY - 2015
TI - Electrochemical Activity of Wedelolactone and Probing its Interaction with DNA Using Voltammetry at a Carbon Electrode
JF - Electroanalysis
VL - 27
IS - 10
SP - 2268-2271
EP - 2268-2271
PB - WILEY-VCH Verlag GmbH
SN - 10400397
KW - Wedelolactone
KW - Electrochemistry
KW - Graphite electrode
KW - DNA
KW - Doxorubicin
UR - http://onlinelibrary.wiley.com/doi/10.1002/elan.201500177/epdf
L2 - http://onlinelibrary.wiley.com/doi/10.1002/elan.201500177/epdf
N2 - Wedelolactone (WLA) is a polyphenolic coumestan derivative found in extracts of plants used in traditional medicine. Due to its cytostatic activity, WLA is one of natural compounds tested as potential anticancer drugs. In this work we for the first time studied electrochemical properties of WLA using cyclic (CV) and square-wave (SWV) voltammetry at the basal-plane pyrolytic graphite electrode. A reversible pair of peaks, corresponding to catechol/o-benzoquinone redox system, was observed using CV around 0.275V vs. Ag|AgCl|3M KCl reference electrode. Measurements of SWV signal of WLA in the presence of single- or double-stranded DNA suggested a weak interaction without evident preference for double-stranded DNA. An indirect assay, employing electroactive DNA intercalator doxorubicin as competitor, confirmed absence of intercalative DNA binding of WLA.
ER -
ČERVEŇ, Jiří, Luděk HAVRAN, Petr PEČINKA a Miroslav FOJTA. Electrochemical Activity of Wedelolactone and Probing its Interaction with DNA Using Voltammetry at a Carbon Electrode. \textit{Electroanalysis}. WEINHEIM: WILEY-VCH Verlag GmbH, 2015, roč.~27, č.~10, s.~2268-2271. ISSN~1040-0397. doi:10.1002/elan.201500177.
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