| HEGYI, Hedvig. Enhancer-promoter interaction facilitated by transiently forming G-quadruplexes. Scientific Reports. LONDON: NATURE PUBLISHING GROUP, 2015, roč. 5, march, s. "nestránkováno", 6 s. ISSN 2045-2322. doi:10.1038/srep09165. |
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@article{1322811,
author = {Hegyi, Hedvig},
article_location = {LONDON},
article_number = {march},
doi = {http://dx.doi.org/10.1038/srep09165},
keywords = {REGULATORY MOTIFS; GENOME-WIDE; DNA; LONG; TRANSCRIPTION; SEQUENCES},
language = {eng},
issn = {2045-2322},
journal = {Scientific Reports},
title = {Enhancer-promoter interaction facilitated by transiently forming G-quadruplexes},
url = {http://www.nature.com/articles/srep09165},
volume = {5},
year = {2015}
}
TY - JOUR
ID - 1322811
AU - Hegyi, Hedvig
PY - 2015
TI - Enhancer-promoter interaction facilitated by transiently forming G-quadruplexes
JF - Scientific Reports
VL - 5
IS - march
SP - "nestránkováno"
EP - "nestránkováno"
PB - NATURE PUBLISHING GROUP
SN - 20452322
KW - REGULATORY MOTIFS
KW - GENOME-WIDE
KW - DNA
KW - LONG
KW - TRANSCRIPTION
KW - SEQUENCES
UR - http://www.nature.com/articles/srep09165
L2 - http://www.nature.com/articles/srep09165
N2 - G-quadruplexes are guanine-rich nucleic acid sequences capable of forming a four-stranded structure through Hoogsteen hydrogen bonding. G-quadruplexes are highly concentrated near promoters and transcription start sites suggesting a role in gene regulation. They are less often found on the template than non-template strand where they either inhibit or enhance transcription, respectively. However, their potential role in enhancers and other distal regulatory elements has not been assessed yet. Here we show that DNAse hypersensitive (DHS) cis-regulatory elements are also enriched in Gs and their G-content correlate with that of their respective promoters. Besides local G4s, the distal cis regions may form G-quadruplexes together with the promoters, each contributing half a G4. This model is supported more for the non-template strand and we hypothesised that the G4 forming capability of the promoter and the enhancer non-template strand could facilitate their binding together and making the DHS regions accessible for the transcription factory.
ER -
HEGYI, Hedvig. Enhancer-promoter interaction facilitated by transiently forming G-quadruplexes. \textit{Scientific Reports}. LONDON: NATURE PUBLISHING GROUP, 2015, roč.~5, march, s.~''nestránkováno'', 6 s. ISSN~2045-2322. doi:10.1038/srep09165.
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