Detailed Information on Publication Record
2016
ACE Insertion/Deletion Polymorphism Associated with Caries in Permanent but Not Primary Dentition in Czech Children
BOŘILOVÁ LINHARTOVÁ, Petra, Jakub KAŠTOVSKÝ, Michaela BARTOŠOVÁ, Kristína MUSILOVÁ, Lenka ŽÁČKOVÁ et. al.Basic information
Original name
ACE Insertion/Deletion Polymorphism Associated with Caries in Permanent but Not Primary Dentition in Czech Children
Name in Czech
ASOCIACE I/D ACE POLYMORFIZMU SE ZUBNÍM KAZEM VE STÁLÉ, ALE NE DOČASNÉ DENTICI U ČESKÝCH DĚTÍ
Authors
BOŘILOVÁ LINHARTOVÁ, Petra (203 Czech Republic, belonging to the institution), Jakub KAŠTOVSKÝ (203 Czech Republic, belonging to the institution), Michaela BARTOŠOVÁ (703 Slovakia, belonging to the institution), Kristína MUSILOVÁ (203 Czech Republic, belonging to the institution), Lenka ŽÁČKOVÁ (203 Czech Republic, belonging to the institution), Martina KUKLETOVÁ (203 Czech Republic, belonging to the institution), Lubomír KUKLA (203 Czech Republic, belonging to the institution) and Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, guarantor, belonging to the institution)
Edition
Caries Research, Basel, Karger, 2016, 0008-6568
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30200 3.2 Clinical medicine
Country of publisher
Switzerland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 1.811
RIV identification code
RIV/00216224:14110/16:00087758
Organization unit
Faculty of Medicine
UT WoS
000376569700001
Keywords (in Czech)
genový polymorfizmus; ACE; zubní kaz; děti; ELSPAC
Keywords in English
gene polymorphism; ACE; dental caries; children; ELSPAC
Tags
International impact, Reviewed
Změněno: 2/8/2016 13:47, Ing. Mgr. Věra Pospíšilíková
V originále
Objective: Dental caries is a multifactorial, infectious disease where genetic predisposition plays an important role. Insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) has very recently been associated with caries in Polish children. The aim of this study was to analyze ACE I/D polymorphism in a group of caries-free children versus subjects affected by dental caries in the Czech population. Materials and Methods: In this case-control study, 182 caries-free children (with decayed/missing/filled teeth, DMFT = 0), 561 subjects with dental caries (DMFT 1) aged 13–15 years and 220 children aged 2–6 years with early childhood caries (ECC, dmft 1) were included. Genotype determination of ACE I/D polymorphism in intron 16 was based on the TaqMan method. Results: Although no significant differences in the allele or genotype frequencies between the cariesfree children and those affected by dental caries were observed, statistically significant differences between the children with DMFT = 0 and the subgroup of 179 patients with high caries experience (DMFT 4; p < 0.01 and p < 0.05, respectively) were detected. The comparison of DD versus II+ID genotype frequencies between the patients with DMFT 1 or DMFT 4 and healthy children also showed significant differences (31.5% or 35.6% vs. 23.6%, p < 0.05 or p < 0.01, respectively). A gender-based analysis identified a significant difference in the DD versus II+ID genotype frequencies only in girls (p < 0.05). In contrast, no significant association of ACE I/D polymorphism with ECC in young children was found (p > 0.05). Conclusions: ACE I/D polymorphism may be associated with caries in permanent but not primary dentition, especially in girls in the Czech population.
In Czech
Cílem studie bylo analyzovat ACE I/D polymorfizmus ve skupině dětí bez zubního kazu vs. u dětí s kazem v české populaci.
Links
| GB14-37368G, research and development project |
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| MUNI/A/1359/2014, interní kód MU |
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| MUNI/M/1075/2013, interní kód MU |
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| NT11405, research and development project |
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