| BOŘILOVÁ LINHARTOVÁ, Petra, Jakub KAŠTOVSKÝ, Světlana LUČANOVÁ, Jirina BARTOVA, Hana POSKEROVÁ, Jan VOKURKA, Antonín FASSMANN, Kateřina KAŇKOVÁ and Lydie IZAKOVIČOVÁ HOLLÁ. Interleukin-17A Gene Variability in Patients with Type 1 Diabetes Mellitus and Chronic Periodontitis: Its Correlation with IL-17 Levels and the Occurrence of Periodontopathic Bacteria. Mediators of Inflammation. New York: Hindawi Publishing Corporation, 2016, vol. 2016, "neuvedeno", p. 1-9. ISSN 0962-9351. Available from: https://dx.doi.org/10.1155/2016/2979846. |
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@article{1322888,
author = {Bořilová Linhartová, Petra and Kaštovský, Jakub and Lučanová, Světlana and Bartova, Jirina and Poskerová, Hana and Vokurka, Jan and Fassmann, Antonín and Kaňková, Kateřina and Izakovičová Hollá, Lydie},
article_location = {New York},
article_number = {"neuvedeno"},
doi = {http://dx.doi.org/10.1155/2016/2979846},
keywords = {Interleukin-17; gene polymorphism; periodonthopatic bacteria; chronic periodontitis; type 1 diabetes mellitus},
language = {eng},
issn = {0962-9351},
journal = {Mediators of Inflammation},
title = {Interleukin-17A Gene Variability in Patients with Type 1 Diabetes Mellitus and Chronic Periodontitis: Its Correlation with IL-17 Levels and the Occurrence of Periodontopathic Bacteria},
volume = {2016},
year = {2016}
}
TY - JOUR
ID - 1322888
AU - Bořilová Linhartová, Petra - Kaštovský, Jakub - Lučanová, Světlana - Bartova, Jirina - Poskerová, Hana - Vokurka, Jan - Fassmann, Antonín - Kaňková, Kateřina - Izakovičová Hollá, Lydie
PY - 2016
TI - Interleukin-17A Gene Variability in Patients with Type 1 Diabetes Mellitus and Chronic Periodontitis: Its Correlation with IL-17 Levels and the Occurrence of Periodontopathic Bacteria
JF - Mediators of Inflammation
VL - 2016
IS - "neuvedeno"
SP - 1-9
EP - 1-9
PB - Hindawi Publishing Corporation
SN - 09629351
KW - Interleukin-17
KW - gene polymorphism
KW - periodonthopatic bacteria
KW - chronic periodontitis
KW - type 1 diabetes mellitus
N2 - Interleukin-17 contributes to the pathogenesis of type 1 diabetes mellitus (T1DM) and chronic periodontitis (CP). We analyzed IL-17A -197A/G and IL-17F +7488C/T polymorphisms in T1DM and CP and determined their associations with IL-17 production and occurrence of periopathogens. Totally 154 controls, 125 T1DM, and 244 CP patients were genotyped using 5'. nuclease TaqMan (R) assays. Bacterial colonization was investigated by a DNA-microarray kit. Production of IL-17 after in vitro stimulation of mononuclear cells by mitogens and bacteria was examined by the Luminex system. Although no differences in the allele/genotype frequencies between patients with CP and T1DM CP were found, the IL-17A -197 A allele increased the risk of T1DM (P < 5). Levels of HbA1c were significantly elevated in carriers of the A allele in T1DM patients (P < 0.05). Production of IL-17 by mononuclear cells of CP patients (unstimulated/stimulated by Porphyromonas gingivalis) was associated with IL-17A A allele (P < 0.05). IL-17A polymorphism increased the number of Tannerella forsythia and Treponema denticola in patients with CP and T1DM + CP, respectively (P < 0.05). IL-17A gene variability may influence control of T1DM and the "red complex" bacteria occurrence in patients with CP and T1DM + CP. Our findings demonstrated the functional relevance of the IL-17A polymorphism with higher IL-17 secretion in individuals with A allele.
ER -
BOŘILOVÁ LINHARTOVÁ, Petra, Jakub KAŠTOVSKÝ, Světlana LUČANOVÁ, Jirina BARTOVA, Hana POSKEROVÁ, Jan VOKURKA, Antonín FASSMANN, Kateřina KAŇKOVÁ and Lydie IZAKOVIČOVÁ HOLLÁ. Interleukin-17A Gene Variability in Patients with Type 1 Diabetes Mellitus and Chronic Periodontitis: Its Correlation with IL-17 Levels and the Occurrence of Periodontopathic Bacteria. \textit{Mediators of Inflammation}. New York: Hindawi Publishing Corporation, 2016, vol.~2016, ''neuvedeno'', p.~1-9. ISSN~0962-9351. Available from: https://dx.doi.org/10.1155/2016/2979846.
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