KUBACKOVA, Katerina, Bohuslav MELICHAR, Zbyněk BORTLÍČEK, Tomáš PAVLÍK, Alexandr POPRACH, Marek SVOBODA, Radek LAKOMY, Rostislav VYZULA, Igor KISS, Ladislav DUŠEK, Jana PRAUSOVA and Tomas BUCHLER. Comparison of Two Prognostic Models in Patients with Metastatic Renal Cancer Treated with Sunitinib: a Retrospective, Registry-Based Study. Targeted Oncology. Dordrecht: Springer, 2015, vol. 10, No 4, p. 557-563. ISSN 1776-2596. Available from: https://dx.doi.org/10.1007/s11523-015-0366-9. |
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@article{1323991, author = {Kubackova, Katerina and Melichar, Bohuslav and Bortlíček, Zbyněk and Pavlík, Tomáš and Poprach, Alexandr and Svoboda, Marek and Lakomy, Radek and Vyzula, Rostislav and Kiss, Igor and Dušek, Ladislav and Prausova, Jana and Buchler, Tomas}, article_location = {Dordrecht}, article_number = {4}, doi = {http://dx.doi.org/10.1007/s11523-015-0366-9}, keywords = {CELL CARCINOMA; TARGETED THERAPY; SURVIVAL; VALIDATION; PROGRESSION; CYTOKINES; CRITERIA; DATABASE}, language = {eng}, issn = {1776-2596}, journal = {Targeted Oncology}, title = {Comparison of Two Prognostic Models in Patients with Metastatic Renal Cancer Treated with Sunitinib: a Retrospective, Registry-Based Study}, volume = {10}, year = {2015} }
TY - JOUR ID - 1323991 AU - Kubackova, Katerina - Melichar, Bohuslav - Bortlíček, Zbyněk - Pavlík, Tomáš - Poprach, Alexandr - Svoboda, Marek - Lakomy, Radek - Vyzula, Rostislav - Kiss, Igor - Dušek, Ladislav - Prausova, Jana - Buchler, Tomas PY - 2015 TI - Comparison of Two Prognostic Models in Patients with Metastatic Renal Cancer Treated with Sunitinib: a Retrospective, Registry-Based Study JF - Targeted Oncology VL - 10 IS - 4 SP - 557-563 EP - 557-563 PB - Springer SN - 17762596 KW - CELL CARCINOMA KW - TARGETED THERAPY KW - SURVIVAL KW - VALIDATION KW - PROGRESSION KW - CYTOKINES KW - CRITERIA KW - DATABASE N2 - The study aimed to compare two prognostic models in terms of progression-free survival (PFS), median overall survival (OS), and 1-year survival in patients treated first-line with sunitinib for metastatic renal cell carcinoma (mRCC). Data from patients who met prognostic model criteria for recording of baseline parameters and outcomes in the Czech Patient Registry RENal Information System (RENIS) were included in the retrospective analysis (n = 495). Performance of the modified Memorial Sloan Kettering Cancer Center (MSKCC) model and International Database Consortium (IDC) model was compared. PFS and OS were estimated using the Kaplan-Meier method. The statistical significance of differences in Kaplan-Meier estimates was assessed using the log-rank test. Median OS for prognostic groups according to MSKCC and IDC criteria, respectively, was 39.5 months (95 % confidence interval [CI]: 23.9-55.2) versus 44.3 months (95 % CI: 31.6-56.9) for favourable-risk patients (no adverse factors), 28.5 months (95 % CI: 20.1-36.8) versus 24.8 months (95 % CI: 19.8-29.8) for intermediate-risk patients (1-2 adverse factors), and 10.6 months (95 % CI: 6.3-14.8) versus 9.3 months (95 % CI: 5.1-13.5) for poor-risk patients (a parts per thousand yen3 adverse factors). The majority of MSKCC poor-risk patients (54.1 %, n = 72) were reclassified as intermediate-risk using IDC criteria, and 20.2 % (n = 61) of MSKCC intermediate-risk patients were reclassified to the IDC favourable-risk group. Both prognostic models were validated in the present cohort. Use of the IDC model resulted in an upward shift in prognostic assessment compared to the MSKCC model. ER -
KUBACKOVA, Katerina, Bohuslav MELICHAR, Zbyněk BORTLÍČEK, Tomáš PAVLÍK, Alexandr POPRACH, Marek SVOBODA, Radek LAKOMY, Rostislav VYZULA, Igor KISS, Ladislav DUŠEK, Jana PRAUSOVA and Tomas BUCHLER. Comparison of Two Prognostic Models in Patients with Metastatic Renal Cancer Treated with Sunitinib: a Retrospective, Registry-Based Study. \textit{Targeted Oncology}. Dordrecht: Springer, 2015, vol.~10, No~4, p.~557-563. ISSN~1776-2596. Available from: https://dx.doi.org/10.1007/s11523-015-0366-9.
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