SAGUNER, AM, S GANAHL, Andrea KRAUS, SH BALDINGER, A MEDEIROS-DOMINGO, AR SAGUNER, SA MUELLER-BURRI, T WOLBER, LM HAEGELI, N KRASNIQI, FC TANNER, J STEFFEL, C BRUNCKHORST a F DURU. Clinical Role of Atrial Arrhythmias in Patients With Arrhythmogenic Right Ventricular Dysplasia. Circulation Journal. Tokyo: Japanese Circulation Soc, 2014, roč. 78, č. 12, s. 2854-2861. ISSN 1346-9843. doi:10.1253/circj.CJ-14-0474.
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Základní údaje
Originální název Clinical Role of Atrial Arrhythmias in Patients With Arrhythmogenic Right Ventricular Dysplasia
Autoři SAGUNER, AM, S GANAHL, Andrea KRAUS, SH BALDINGER, A MEDEIROS-DOMINGO, AR SAGUNER, SA MUELLER-BURRI, T WOLBER, LM HAEGELI, N KRASNIQI, FC TANNER, J STEFFEL, C BRUNCKHORST a F DURU.
Vydání Circulation Journal, Tokyo, Japanese Circulation Soc, 2014, 1346-9843.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 3.940
Doi http://dx.doi.org/10.1253/circj.CJ-14-0474
UT WoS 000346698300013
Klíčová slova anglicky Arrhythmogenic right ventricular dysplasia; Atrial fibrillation; Atrial flutter; Cardiomyopathy
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Mgr. Andrea Kraus, M.Sc., Ph.D., učo 238225. Změněno: 12. 1. 2016 23:07.
Anotace
Background: The clinical role of atrial fibrillation/atrial flutter (AF-AFl) and variables predicting these arrhythmias are not well defined in patients with arrhythmogenic right ventricular dysplasia (ARVD). We hypothesized that transthoracic echocardiography (TTE) and 12-lead electrocardiography (ECG) would be helpful in predicting AF-AFl in these patients. Methods and Results: ECGs and TTEs of 90 patients diagnosed with definite or borderline ARVD (2010 Task Force Criteria) were analyzed. Data were compared in (1) patients with AF-AFl and (2) all other patients. A total of 18 (20%) patients experienced AF-AFl during a median follow-up of 5.8 years (interquartile range 2.0-10.4). Kaplan-Meier analysis revealed reduced times to AF-AFl among patients with echocardiographic RV fractional area change <27% (P<0.001), left atrial diameter >= 24.4 mm/m(2) (parasternal long-axis, P=0.001), and right atrial short-axis diameter >= 22.1 mm/m(2) (apical 4-chamber view, P=0.05). From all ECG variables, P mitrale conferred the highest hazard ratio (3.37, 95% confidence interval 0.92-12.36, P=0.067). Five patients with AF-AFl experienced inappropriate implantable cardioverter-defibrillator (ICD) shocks compared with 4 without AF-AFl (36% vs. 9%, P=0.03). AF-AFl was more prevalent in heart-transplant patients and those who died of cardiac causes (56% vs. 16%, P=0.014). Conclusions: AF-AFl is associated with inappropriate ICD shocks, heart transplantation, and cardiac death in patients with ARVD. Evidence of reduced RV function and atrial dilation helps to identify the ARVD patients at increased risk for AF-AFl.
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