J 2015

Electrocardiographic features of disease progression in arrhythmogenic right ventricular cardiomyopathy/dysplasia

SAGUNER, AM, S GANAHL, Andrea KRAUS, SH BALDINGER, D AKDIS et. al.

Basic information

Original name

Electrocardiographic features of disease progression in arrhythmogenic right ventricular cardiomyopathy/dysplasia

Authors

SAGUNER, AM, S GANAHL, Andrea KRAUS, SH BALDINGER, D AKDIS, AR SAGUNER, T WOLBER, LM HAEGELI, J STEFFEL, N KRASNIQI, TF LUSCHER, FC TANNER, C BRUNCKHORST and F DURU

Edition

BMC Cardiovascular Disorders, London, Biomed Central Ltd, 2015, 1471-2261

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 1.916

DOI

UT WoS

000348674300002

Keywords in English

Arrhythmogenic Right Ventricular; Cardiomyopathy; Dysplasia; Electrocardiography; T wave inversion

Tags

International impact, Reviewed
Změněno: 12/1/2016 23:11, Mgr. Andrea Kraus, M.Sc., Ph.D.

Abstract

V originále

Background: Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is considered a progressive cardiomyopathy. However, data on the clinical features of disease progression are limited. The aim of this study was to assess 12-lead surface electrocardiographic (ECG) changes during long-term follow-up, and to compare these findings with echocardiographic data in our large cohort of patients with ARVC/D. Methods: Baseline and follow-up ECGs of 111 patients from three tertiary care centers in Switzerland were systematically analyzed with digital calipers by two blinded observers, and correlated with findings from transthoracic echocardiography. Results: The median follow-up was 4 years (IQR 1.9-9.2 years). ECG progression was significant for epsilon waves (baseline 14% vs. follow-up 31%, p = 0.01) and QRS duration (111 ms vs. 114 ms, p = 0.04). Six patients with repolarization abnormalities according to the 2010 Task Force Criteria at baseline did not display these criteria at follow-up, whereas in all patients with epsilon waves at baseline these depolarization abnormalities also remained at follow-up. T wave inversions in inferior leads were common (36% of patients at baseline), and were significantly associated with major repolarization abnormalities (p = 0.02), extensive echocardiographic right ventricular involvement (p = 0.04), T wave inversions in lateral precordial leads (p = 0.05), and definite ARVC/D (p = 0.05). Conclusions: Our data supports the concept that ARVC/D is generally progressive, which can be detected by 12-lead surface ECG. Repolarization abnormalities may disappear during the course of the disease. Furthermore, the presence of T wave inversions in inferior leads is common in ARVC/D.