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@article{1331397,
author = {Pavlová, Tereza and Novák, Jan and Bienertová Vašků, Julie},
article_location = {Shannon},
article_number = {NOV 2015},
doi = {http://dx.doi.org/10.1016/j.jri.2015.09.004},
keywords = {Preterm labor; Pre-eclampsia; Gestational diabetes mellitus; Maternal plasma; Sirtuins; Visfatin},
language = {eng},
issn = {0165-0378},
journal = {Journal of Reproductive Immunology},
title = {The role of visfatin (PBEF/Nampt) in pregnancy complications},
volume = {112},
year = {2015}
}
TY - JOUR
ID - 1331397
AU - Pavlová, Tereza - Novák, Jan - Bienertová Vašků, Julie
PY - 2015
TI - The role of visfatin (PBEF/Nampt) in pregnancy complications
JF - Journal of Reproductive Immunology
VL - 112
IS - NOV 2015
SP - 102-110
EP - 102-110
PB - Elsevier Ireland LTD
SN - 01650378
KW - Preterm labor
KW - Pre-eclampsia
KW - Gestational diabetes mellitus
KW - Maternal plasma
KW - Sirtuins
KW - Visfatin
N2 - Visfatin (PBEF/Nampt) is an adipocytokine that exerts pleiotropic effects within the human body, particularly affecting its metabolism and immunity. Visfatin was originally identified as being secreted by peripheral blood lymphocytes acting as a pre-B-cell colony-enhancing factor (PBEF). However, it was subsequently reported to be expressed in almost every tissue of the human body, with visceral fat deposits being the main source of visfatin. In addition to its secreted form, visfatin may also be found intracellularly where it functions as a nicotinamide phosphoribosyltransferase (Nampt). Visfatin maternal plasma concentrations increase during pregnancy, suggesting its important role in this complicated process. Alterations in visfatin level also take place in patients during pregnancy complications. This review focuses on the ones that most commonly occur in connection with visfatin: preterm labor, pre-eclampsia and gestational diabetes mellitus. The review aims to provide a better understanding of the role of visfatin during pregnancy and the causes of its alteration in maternal plasma, highlighting the potential use of visfatin as a diagnostic marker of pregnancy complications in the future. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
ER -
PAVLOVÁ, Tereza, Jan NOVÁK and Julie BIENERTOVÁ VAŠKŮ. The role of visfatin (PBEF/Nampt) in pregnancy complications. \textit{Journal of Reproductive Immunology}. Shannon: Elsevier Ireland LTD, 2015, vol.~112, NOV 2015, p.~102-110. ISSN~0165-0378. Available from: https://dx.doi.org/10.1016/j.jri.2015.09.004.
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