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@article{1331397, author = {Pavlová, Tereza and Novák, Jan and Bienertová Vašků, Julie}, article_location = {Shannon}, article_number = {NOV 2015}, doi = {http://dx.doi.org/10.1016/j.jri.2015.09.004}, keywords = {Preterm labor; Pre-eclampsia; Gestational diabetes mellitus; Maternal plasma; Sirtuins; Visfatin}, language = {eng}, issn = {0165-0378}, journal = {Journal of Reproductive Immunology}, title = {The role of visfatin (PBEF/Nampt) in pregnancy complications}, volume = {112}, year = {2015} }
TY - JOUR ID - 1331397 AU - Pavlová, Tereza - Novák, Jan - Bienertová Vašků, Julie PY - 2015 TI - The role of visfatin (PBEF/Nampt) in pregnancy complications JF - Journal of Reproductive Immunology VL - 112 IS - NOV 2015 SP - 102-110 EP - 102-110 PB - Elsevier Ireland LTD SN - 01650378 KW - Preterm labor KW - Pre-eclampsia KW - Gestational diabetes mellitus KW - Maternal plasma KW - Sirtuins KW - Visfatin N2 - Visfatin (PBEF/Nampt) is an adipocytokine that exerts pleiotropic effects within the human body, particularly affecting its metabolism and immunity. Visfatin was originally identified as being secreted by peripheral blood lymphocytes acting as a pre-B-cell colony-enhancing factor (PBEF). However, it was subsequently reported to be expressed in almost every tissue of the human body, with visceral fat deposits being the main source of visfatin. In addition to its secreted form, visfatin may also be found intracellularly where it functions as a nicotinamide phosphoribosyltransferase (Nampt). Visfatin maternal plasma concentrations increase during pregnancy, suggesting its important role in this complicated process. Alterations in visfatin level also take place in patients during pregnancy complications. This review focuses on the ones that most commonly occur in connection with visfatin: preterm labor, pre-eclampsia and gestational diabetes mellitus. The review aims to provide a better understanding of the role of visfatin during pregnancy and the causes of its alteration in maternal plasma, highlighting the potential use of visfatin as a diagnostic marker of pregnancy complications in the future. (C) 2015 Elsevier Ireland Ltd. All rights reserved. ER -
PAVLOVÁ, Tereza, Jan NOVÁK and Julie BIENERTOVÁ VAŠKŮ. The role of visfatin (PBEF/Nampt) in pregnancy complications. \textit{Journal of Reproductive Immunology}. Shannon: Elsevier Ireland LTD, 2015, vol.~112, NOV 2015, p.~102-110. ISSN~0165-0378. Available from: https://dx.doi.org/10.1016/j.jri.2015.09.004.
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