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@article{1331432,
author = {Héžová, Renata and Kovaříková, Alena and Srovnal, Josef and Zemanová, Milada and Harustiak, Tomáš and Ehrmann, Jiří and Hajdúch, Marian and Šachlová, Milana and Svoboda, Marek and Slabý, Ondřej},
article_location = {Dordrecht},
article_number = {6},
doi = {http://dx.doi.org/10.1007/s13277-015-4656-8},
keywords = {Esophageal adenocarcinoma; Esophageal squamous cell carcinoma; miR-205; Tumor suppressor; Oncogene},
language = {eng},
issn = {1010-4283},
journal = {Tumor Biology},
title = {MiR-205 functions as a tumor suppressor in adenocarcinoma and an oncogene in squamous cell carcinoma of esophagus},
url = {http://link.springer.com/article/10.1007%2Fs13277-015-4656-8},
volume = {37},
year = {2016}
}
TY - JOUR
ID - 1331432
AU - Héžová, Renata - Kovaříková, Alena - Srovnal, Josef - Zemanová, Milada - Harustiak, Tomáš - Ehrmann, Jiří - Hajdúch, Marian - Šachlová, Milana - Svoboda, Marek - Slabý, Ondřej
PY - 2016
TI - MiR-205 functions as a tumor suppressor in adenocarcinoma and an oncogene in squamous cell carcinoma of esophagus
JF - Tumor Biology
VL - 37
IS - 6
SP - 8007-8018
EP - 8007-8018
PB - Springer
SN - 10104283
KW - Esophageal adenocarcinoma
KW - Esophageal squamous cell carcinoma
KW - miR-205
KW - Tumor suppressor
KW - Oncogene
UR - http://link.springer.com/article/10.1007%2Fs13277-015-4656-8
L2 - http://link.springer.com/article/10.1007%2Fs13277-015-4656-8
N2 - Esophageal cancer is a malignant disease with poor prognosis, increasing incidence, and ineffective treatment options. MicroRNAs are post-transcriptional regulators of gene expression involved in many biological processes including carcinogenesis. We determined miR-205 expression levels in tumor/non-tumor tissues of 45 esophageal cancer patients using qPCR and found that decreased level of miR-205 in tumor tissue correlates with poor overall survival in esophageal adenocarcinoma patients. Further, we observed significantly higher levels of miR-205 in tumor tissue of esophageal squamous cell carcinoma. Ectopic overexpression of miR-205 in adenocarcinoma cell line SK-GT-4 led to decreased cell proliferation, cell cycle arrest in G1, and decreased migration ability. Conversely, in squamous cell line KYSE-150, same effects like inhibition of proliferation, migration, and colony-forming potential and cell cycle arrest in G2 were observed after silencing of miR-205. We performed global gene expression profiling and revealed that suppressive functioning of miR-205 in adenocarcinoma could be realized through regulation of epithelial-mesenchymal transition (EMT), whereas oncogenic in squamous cell carcinoma by regulation of metalloproteinase 10. Our results suggest that miR-205 could serve as biomarker in esophageal cancer and acts as a tumor suppressor in esophageal adenocarcinoma and oncogene in esophageal squamous cell carcinoma.
ER -
HÉŽOVÁ, Renata, Alena KOVAŘÍKOVÁ, Josef SROVNAL, Milada ZEMANOVÁ, Tomáš HARUSTIAK, Jiří EHRMANN, Marian HAJDÚCH, Milana ŠACHLOVÁ, Marek SVOBODA and Ondřej SLABÝ. MiR-205 functions as a tumor suppressor in adenocarcinoma and an oncogene in squamous cell carcinoma of esophagus. \textit{Tumor Biology}. Dordrecht: Springer, 2016, vol.~37, No~6, p.~8007-8018. ISSN~1010-4283. Available from: https://dx.doi.org/10.1007/s13277-015-4656-8.
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