| BUCHLER, Tomas, Zbyněk BORTLÍČEK, Alexandr POPRACH, Tomáš PAVLÍK, Veronika VESKRNOVA, Michaela HONZIRKOVA, Milada ZEMANOVA, Ondrej FIALA, Kateřina KUBÁČKOVÁ, Ondřej SLABÝ, Marek SVOBODA, Rostislav VYZULA, Ladislav DUŠEK and Bohuslav MELICHAR. Outcomes for Patients with Metastatic Renal Cell Carcinoma Achieving a Complete Response on Targeted Therapy: A Registry-based Analysis. European Urology. Amsterdam: Elsevier Science Inc., 2016, vol. 70, No 3, p. 469-475. ISSN 0302-2838. Available from: https://dx.doi.org/10.1016/j.eururo.2015.12.031. |
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@article{1331436,
author = {Buchler, Tomas and Bortlíček, Zbyněk and Poprach, Alexandr and Pavlík, Tomáš and Veskrnova, Veronika and Honzirkova, Michaela and Zemanova, Milada and Fiala, Ondrej and Kubáčková, Kateřina and Slabý, Ondřej and Svoboda, Marek and Vyzula, Rostislav and Dušek, Ladislav and Melichar, Bohuslav},
article_location = {Amsterdam},
article_number = {3},
doi = {http://dx.doi.org/10.1016/j.eururo.2015.12.031},
keywords = {Renal cell carcinoma; Targeted therapy; Complete response; Survival},
language = {eng},
issn = {0302-2838},
journal = {European Urology},
title = {Outcomes for Patients with Metastatic Renal Cell Carcinoma Achieving a Complete Response on Targeted Therapy: A Registry-based Analysis.},
volume = {70},
year = {2016}
}
TY - JOUR
ID - 1331436
AU - Buchler, Tomas - Bortlíček, Zbyněk - Poprach, Alexandr - Pavlík, Tomáš - Veskrnova, Veronika - Honzirkova, Michaela - Zemanova, Milada - Fiala, Ondrej - Kubáčková, Kateřina - Slabý, Ondřej - Svoboda, Marek - Vyzula, Rostislav - Dušek, Ladislav - Melichar, Bohuslav
PY - 2016
TI - Outcomes for Patients with Metastatic Renal Cell Carcinoma Achieving a Complete Response on Targeted Therapy: A Registry-based Analysis.
JF - European Urology
VL - 70
IS - 3
SP - 469-475
EP - 469-475
PB - Elsevier Science Inc.
SN - 03022838
KW - Renal cell carcinoma
KW - Targeted therapy
KW - Complete response
KW - Survival
N2 - BACKGROUND: It is currently not known whether treatment with anti-vascular endothelial growth factor agents for metastatic renal cell carcinoma (mRCC) can be safely discontinued in patients achieving a complete response (CR). OBJECTIVE: To assess outcomes for patients with mRCC achieving CR on targeted therapy (TT) and the survival of patients discontinuing TT after CR. DESIGN, SETTING, AND PARTICIPANTS: A national registry was used to identify patients achieving CR during first-line TT using bevacizumab, sunitinib, sorafenib, or pazopanib. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Relationships with outcomes were analysed using a log-rank test. RESULTS AND LIMITATIONS: A total of 100 patients achieving CR were identified out of 2803 patients. The median time to CR was 10.1 mo. Median progression-free survival (PFS) from TT initiation was 3.8 yr (95% confidence interval [CI] 2.9-4.6 yr) and the 5-yr overall survival (OS) was 80% (95% CI 70-91%). Patients discontinuing TT within 1 mo after achieving CR and those continuing TT beyond CR had similar OS (CI for difference in 2-yr post-CR OS -13% to 19%; p=0.3) and PFS (CI for difference in 2-yr post-CR PFS -29% to 17%; p=0.7). The limitations include the retrospective, registry-based data analysis. CONCLUSIONS: Achievement of CR on TT for mRCC was associated with excellent long-term prognosis. No significant differences in post-CR survival were observed between patients discontinuing TT after the date of CR and those who continued on TT, although the wide CIs cannot exclude important differences between the groups. PATIENT SUMMARY: According to this registry-based analysis, patients with metastatic renal cancer with no signs of disease (complete response) after treatment with targeted agents experience excellent long-term survival even if the treatment does not continue beyond the date of complete response.
ER -
BUCHLER, Tomas, Zbyněk BORTLÍČEK, Alexandr POPRACH, Tomáš PAVLÍK, Veronika VESKRNOVA, Michaela HONZIRKOVA, Milada ZEMANOVA, Ondrej FIALA, Kateřina KUBÁČKOVÁ, Ondřej SLABÝ, Marek SVOBODA, Rostislav VYZULA, Ladislav DUŠEK and Bohuslav MELICHAR. Outcomes for Patients with Metastatic Renal Cell Carcinoma Achieving a Complete Response on Targeted Therapy: A Registry-based Analysis. \textit{European Urology}. Amsterdam: Elsevier Science Inc., 2016, vol.~70, No~3, p.~469-475. ISSN~0302-2838. Available from: https://dx.doi.org/10.1016/j.eururo.2015.12.031.
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