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@article{1331446,
author = {Kliszczak, Maciej and Sedláčková, Hana and Pitchai, Ganesha P. and Streicher, Werner W. and Krejčí, Lumír and Hickson, Ian D.},
article_location = {New York},
article_number = {38},
doi = {http://dx.doi.org/10.18632/oncotarget.6342},
keywords = {DNA replication; RecQ helicases; minichromosome maintenance proteins; Chromosome Section},
language = {eng},
issn = {1949-2553},
journal = {Oncotarget},
title = {Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells},
volume = {6},
year = {2015}
}
TY - JOUR
ID - 1331446
AU - Kliszczak, Maciej - Sedláčková, Hana - Pitchai, Ganesha P. - Streicher, Werner W. - Krejčí, Lumír - Hickson, Ian D.
PY - 2015
TI - Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells
JF - Oncotarget
VL - 6
IS - 38
SP - 40464-40479
EP - 40464-40479
PB - Impact Journals LLC
SN - 19492553
KW - DNA replication
KW - RecQ helicases
KW - minichromosome maintenance proteins
KW - Chromosome Section
N2 - DNA replication is a highly coordinated process that is initiated at multiple replication origins in eukaryotes. These origins are bound by the origin recognition complex (ORC), which subsequently recruits the Mcm2-7 replicative helicase in a Cdt1/Cdc6-dependent manner. In budding yeast, two essential replication factors, Sld2 and Mcm10, are then important for the activation of replication origins. In humans, the putative Sld2 homolog, RECQ4, interacts with MCM10. Here, we have identified two mutants of human RECQ4 that are deficient in binding to MCM10. We show that these RECQ4 variants are able to complement the lethality of an avian cell RECQ4 deletion mutant, indicating that the essential function of RECQ4 in vertebrates is unlikely to require binding to MCM10. Nevertheless, we show that the RECQ4-MCM10 interaction is important for efficient replication origin firing.
ER -
KLISZCZAK, Maciej, Hana SEDLÁČKOVÁ, Ganesha P. PITCHAI, Werner W. STREICHER, Lumír KREJČÍ and Ian D. HICKSON. Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells. \textit{Oncotarget}. New York: Impact Journals LLC, 2015, vol.~6, No~38, p.~40464-40479. ISSN~1949-2553. Available from: https://dx.doi.org/10.18632/oncotarget.6342.
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