HOŘÁK, Martin, Jan NOVÁK and Julie BIENERTOVÁ VAŠKŮ. Muscle-specific microRNAs in skeletal muscle development. Developmental Biology. San Diego: Academic Press Inc., 2016, vol. 410, No 1, p. 1-13. ISSN 0012-1606. Available from: https://dx.doi.org/10.1016/j.ydbio.2015.12.013.
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Basic information
Original name Muscle-specific microRNAs in skeletal muscle development
Authors HOŘÁK, Martin (203 Czech Republic, guarantor, belonging to the institution), Jan NOVÁK (203 Czech Republic, belonging to the institution) and Julie BIENERTOVÁ VAŠKŮ (203 Czech Republic, belonging to the institution).
Edition Developmental Biology, San Diego, Academic Press Inc. 2016, 0012-1606.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10605 Developmental biology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW Full Text
Impact factor Impact factor: 2.944
RIV identification code RIV/00216224:14310/16:00089279
Organization unit Faculty of Science
Doi http://dx.doi.org/10.1016/j.ydbio.2015.12.013
UT WoS 000369124700001
Keywords in English miR-1; miR-133; miR-206; miR-208b; miR-486; miR-499
Tags AKR, EL OK, podil, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Marie Šípková, DiS., učo 437722. Changed: 16/12/2019 14:18.
Abstract
Proper muscle function constitutes a precondition for good heath and an active lifestyle during an individual's lifespan and any deviations from normal skeletal muscle development and its functions may lead to numerous health conditions including e.g. myopathies and increased mortality. It is thus not surprising that there is an increasing need for understanding skeletal muscle developmental processes and the associated molecular pathways, especially as such information could find further uses in therapy. The understanding of complex skeletal muscle developmental networks was broadened with the discovery of microRNA (miRNA) molecules. MicroRNAs are evolutionary conserved small non-coding RNAs capable of negatively regulating gene expression on a post-transcriptional level by means of miRNA-mRNA interaction. Several miRNAs expressed exclusively in muscle have been labeled myomiRs. MyomiRs represent an integral part of skeletal muscle development, i.e. playing a significant role during skeletal muscle proliferation, differentiation and regeneration. The purpose of this review is to provide a summary of current knowledge regarding the involvement of myomiRs in the individual phases of myogenesis and other aspects of skeletal muscle biology, along with an up-to-date list of myomiR target genes and their functions in skeletal muscle and miRNA-related therapeutic approaches and future prospects.
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